线粒体钙单向转运体在神经退行性疾病中的作用研究进展  

Research progress on role of mitochondrial calcium uniporter in neurodegenerative diseases

作　　者：周洁 杨应丽 张梦然 段维霞 ZHOU Jie;YANG Yingli;ZHANG Mengran;DUAN Weixia(School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;Center of Experimental Medicine,First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning,Chongqing 400060,China)

机构地区：[1]南京医科大学公共卫生学院,南京211166 [2]重庆医药高等专科学校附属第一医院实验医学中心/职业病防治与中毒救治重庆市重点实验室,重庆400060

出　　处：《重庆医学》2024年第17期2691-2697,共7页Chongqing Medical Journal

基　　金：重庆市教育委员会科学技术研究项目(KJQN202302827);重庆医药高等专科学校附属第一医院孵化项目(2022-2023ZD01)。

摘　　要：随着全球老龄化加剧,神经退行性疾病的患病率逐年攀升,给社会和家庭带来了沉重的负担,但有效的治疗药物仍然匮乏,迫切需要发现新的治疗靶点和研发新的治疗策略。近年研究发现,线粒体钙单向转运体(MCU)在多种神经退行性疾病中具有重要功能,其表达或功能异常引起神经细胞线粒体钙稳态失衡是神经退行性疾病的重要机制之一,抑制MCU功能可起到良好的神经保护作用,MCU特异性抑制剂在治疗多种神经退行性疾病中已展现出良好前景。为此,该文简述了MCU的结构、功能、调控机制及其特异性抑制剂,重点分析了MCU在不同神经退行性疾病发生、发展中的作用,对深入探索MCU作为神经退行性疾病新的治疗靶点提供参考。With the world aging aggravation,the prevalence of neurodegenerative diseases has risen year by year,which brings a huge burden on society and family.However,the effective treatment drugs are still scarce,there is an urgent need to discover new therapeutic targets and develop new therapeutic strategies.Recent studies have found that the the mitochondrial calcium uniporter(MCU)has an important function in many neurodegenerative diseases,the imbalance of mitochondrial calcium homeostasis caused by its abnormal expression or function is one of the important mechanisms of neurodegenerative diseases.Inhibiting the MCU function can play the good neuroprotective role,the specific inhibitors of MCU have shown the good prospect in treating various neurodegenerative diseases.This paper sketched the structure,function,regulatory mechanism and specific inhibitors of MCU,and focused on analyzing the role of MCU in the occurrence and development of different neurodegenerative diseases in order to provide reference for further exploration of MCU as a new therapeutic target for neurodegenerative diseases.

关 键 词：线粒体钙单向转运体 神经退行性疾病 钙平衡 线粒体钙单向转运体特异性抑制剂 

分 类 号：R741[医药卫生—神经病学与精神病学]