青年乳腺癌与中老年乳腺癌患者临床及病理特征比较  

Comparison of Clinical and Pathological Features between Young and Middle-Aged Breast Cancer Patients

作　　者：张红美 胡丽丽 李平 孙革[2] ZHANG Hongmei;HU Lili;LI Ping;SUN Ge(The Second Department of Ultrasound,the People's Hospital of Langfang City,Langfang,Hebei 065000,China;Department of Pathology,the People's Hospital of Langfang City,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市人民医院超声二科,河北廊坊065000 [2]廊坊市人民医院病理科,河北廊坊065000

出　　处：《临床误诊误治》2024年第15期41-44,共4页Clinical Misdiagnosis & Mistherapy

基　　金：廊坊市科技支撑计划项目(2020013075)。

摘　　要：目的探究青年与中老年乳腺癌患者临床及病理特征。方法选择2020年4月至2022年4月收治的乳腺癌患者120例,依照年龄分为青年组(≤35岁)48例与中老年组(>35岁)72例。比较2组患者一般资料和临床病理特征。结果2组发病部位和肿瘤结节个数比较差异均无统计学意义(P>0.05)。2组T分期、N分期和组织学分级及雌激素受体、孕激素受体阳性率、C-erbB-2蛋白表达、分子分型比较差异均有统计学意义(P<0.05,P<0.01)。2组术后12个月和24个月生存率比较差异无统计学意义(P>0.05)。结论青年乳腺癌与中老年乳腺癌在临床特征和分子分型方面均有着较大差异,需引起临床高度重视,以便尽早诊断、及时治疗。Objective To explore the clinicopathological features of young and middle-aged patients with breast cancer.Methods A total of 120 patients with breast cancer treated from April 2020 to April 2022 were selected and divided into the young group(≤35 years,n=48)and the middle-aged group(>35 years,n=72)according to age.The general data and clinicopathological features of the two groups were compared.Results There was no significant difference in the lesion site and the number of tumor nodules between the two groups(P>0.05).There were significant differences in T stage,N stage,histological grade,estrogen receptor,progesterone receptor positivity rate,C-erbB-2 protein expression and molecular typing between the two groups(P<0.05,P<0.01).There was no significant difference in 12-month and 24-month survival rates between the two groups(P>0.05).Conclusion There are significant differences in clinical characteristics and molecular typing between young breast cancer and middle-aged and elderly breast cancer,which should be paid close attention to in clinical practice for early diagnosis and timely treatment.

关 键 词：乳腺肿瘤 青年人 中老年 肿瘤分期 受体 雌激素 受体 孕激素 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]