Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy  

作　　者：Qibin Han Lang Bai Yinhua Qian Xiaoyu Zhang Juan Wang Jing Zhou Wenguo Cui Yuefeng Hao Xing Yang 

机构地区：[1]Department of Orthopedics,The Affliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University Suzhou215008,P.R.China [2]Department of Orthopedics,Kunshan Hospital of Traditional Chinese Medicine,Suzhou 215300,P.R.China [3]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,P.R.China

出　　处：《Regenerative Biomaterials》2024年第3期92-104,共13页再生生物材料（英文版）

基　　金：the Program of Jiangsu science and technology Department(BK20211083,BE2022737);Jiangsu Graduate Student Cultivation Innovative Engineering Graduate Research and Practice Innovation Program(KYCX21_1578);the Program of Suzhou Health Commission(GSWS2020078,SZXK202111).

摘　　要：Tendinopathy is a common disorder that causes local dysfunction and reduces quality of life.Recent research has indicated that alterations in the inflammatory microenvironment play a vital role in the pathogenesis of tendinopathy.Herein,injectable methacrylate gelatin(GelMA)microspheres(GM)were fabricated and loaded with heparin-dopamine conjugate(HDC)and hepatocyte growth factor(HGF).GM@HDC@HGF were designed to balance the inflammatory microenvironment by inhibiting oxidative stress and inflammation,thereby regulating extracellular matrix(ECM)metabolism and halting tendon degeneration.Combining growth factors with heparin was expected to improve the encaption,the catechol groups on dopamine have adhesion and antioxidant properties,allowing potential attachment at the injured site,and better function synergized with HGF.GM@HDC@HGF injected in situ in rat Achilles tendinopathy(AT)models significantly downregulated oxidative stress and inflammation,and ameliorated ECM degradation.In conclusion,the multifunctional platform developed presents a promising alternative for the treatment of tendinopathy.

关 键 词：TENDINOPATHY oxidative stress INFLAMMATION MICROSPHERES 

分 类 号：R318[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]