Extracellular vesicles derived from mesenchymal stem cells:the wine in Hebe's hands to treat skin aging  

作　　者：Qixiang Gui Neng Ding Zuochao Yao Minjuan Wu Ruifeng Fu Yue Wang Yunpeng Zhao Lie Zhu 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Second Affliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai 20o001,China [2]Department of Plastic and Reconstructive Surgery of Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China [3]Department of Histology and Embryology,Naval Medical University,Shanghai 200433,China [4]Shanghai Key Laboratory of Cell Engineering,Translational Medical Research Center,Naval Medical University,Shanghai 200433,China [5]hanghai Institute of Stem Cell Research and Clinical Translation,Shanghai 200092,China

出　　处：《Precision Clinical Medicine》2024年第2期170-189,共20页精准临床医学（英文）

基　　金：the National Natural Science Foundation of China(Grant No.31971109);Shanghai Key Laboratory of Cell Engineering(Grant No.14DZ2272300);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai.The figures were created with BioRender.com.

摘　　要：Owing to its constant exposure to the external environment and various stimuli,skin ranks among the organs most vulnerable to manifestations of aging.Preventing and delaying skin aging has become one of the prominent research subjects in recent years.Mesenchymal stem celis(MsCs)are multipotent stem cells derived from mesoderm with high self-renewal ability and multilineage differentiation potential.MSC-derived extracellular vesicles(MSC-EVs)are nanoscale biological vesicles that facilitate intercellular communication and regulate biological behavior.Recent studies have shown that MSC-EVs have potential applications in anti-aging therapy due to their anti-inflammatory,anti-oxidative stress,and wound healing promoting abilities.This review presents the latest progress of MSC-EVs in delaying skin aging.It mainly includes the MSC-EVs promoting the proliferation and migration of keratinocytes and fibroblasts,reducing the expression of matrix metalloproteinases,resisting oxidative stress,and regulating inflammation.We then briefly discuss the recently discovered treatment methods of MSc-EVs in the field of skin anti-aging.Moreover,the advantages and limitations of EV-based treatments are also presented.

关 键 词：mesenchymal stem cell extracellular vesicles EXOSOMES skin aging ANTI-AGING PHOTOAGING 

分 类 号：R339.38[医药卫生—人体生理学] R75[医药卫生—基础医学]