吗啡静脉患者自控镇痛治疗难治性癌痛的疗效  

Efficacy of intravenous morphine patient-controlled analgesia in the treatment of refractory cancer pain

作　　者：张超 高文仓 ZHANG Chao;GAO Wencang(Department of Oncology,Peixian People's Hospital,Peixian 221600,CHINA)

机构地区：[1]沛县人民医院肿瘤科,江苏221600 [2]浙江中医药大学附属第二医院肿瘤科

出　　处：《江苏医药》2024年第8期831-833,共3页Jiangsu Medical Journal

摘　　要：目的观察吗啡静脉患者自控镇痛(PCA)治疗难治性癌性疼痛(癌痛)的临床疗效。方法难治性癌痛患者106例随机分为两组,分别采用吗啡静脉PCA(A组,52例)和口服吗啡缓释片镇痛(B组,54例),连续治疗5 d。评估治疗前和治疗第1、3、7天数字评估量表(NRS)评分,记录爆发性疼痛发作次数,观察治疗7 d内不良反应发生情况。结果与治疗前比较,A组治疗第1、3、7天NRS评分降低,爆发性疼痛发作次数减少,且均优于B组(P<0.05或P<0.01)。两组治疗7 d内不良反应发生率相仿(P>0.05)。结论吗啡静脉PCA治疗难治性癌痛的疗效明显,不良反应轻微,优于口服吗啡缓释片。Objective To observe the clinical efficacy of intravenous morphine patient-controlled analgesia(PCA)in the treatment of refractory cancer pain.Methods A total of 106 patients with refractory cancer pain were randomly divided into two groups and treated with intravenous morphine hydrochloride PCA(group A,52 cases)and with oral morphine hydrochloride sustained-release tablets(group B,54 cases).The treatment lasted for 5 days.The scores of numerical rating scale(NRS)were evaluated before and on the 1^(st),3^(rd)and 7^(th)day during treatment.The number of explosive pain attack was recorded.The adverse reactions of the two groups within 7 days during treatment were observed.Results The NRS score and the number of explosive pain attack in group A were decreased on the 1^(st),3^(rd)and 7^(th)day during treatment,which were better in group A than those in group B(P<0.05 or P<0.01).The incidences of adverse reactions of the two groups were similar within 7 days of the treatment(P>0.05).Conclusion Intravenous morphine PCA in the treatment of refractory cancer pain has better clinical efficacy than oral morphine with mild adverse effects.

关 键 词：难治性癌性疼痛 患者自控镇痛 吗啡 

分 类 号：R730[医药卫生—肿瘤]