苍术燥性的研究进展  

Dryness of Atractylodis Rhizoma:A Review

作　　者：姚丁 柯畅 于松洋 许康 刘艳菊 瞿领航 YAO Ding;KE Chang;YU Songyang;XU Kang;LIU Yanju;QU Linghang*(School of Pharmacy,Hubei Processing Engineering and Technology Center of Traditional Chinese Medicine,Hubei Shizhen Laboratory,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]湖北中医药大学药学院,湖北省中药炮制工程技术中心,湖北时珍实验室,武汉430065

出　　处：《中国实验方剂学杂志》2024年第19期292-298,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：湖北省自然科学基金联合基金项目(2023AFD154);国家自然科学基金青年项目(82304722)。

摘　　要：燥性是中医理论的重要概念,其与机体气运转化、病因病机等方面息息相关,燥性作为中药的药性之一,具备燥性的中药类别多样。苍术是温燥之性的代表药,具燥湿健脾功能,由于其燥性强烈,会产生一定不良反应,临床多以麸炒苍术入药。苍术的燥性与药效密切相关,但燥与效的深层关联机制尚不清楚。目前,关于燥性中药的研究逐年增多,但仍存在研究不够系统、挖掘不够深入、燥效机制研究缺乏等问题,从而限制了炮制缓燥理论的突破,阻碍了燥性中药在临床上的精准应用。为此,该文通过检索国内外文献,较全面地综述了不同中药燥性表征指标差异,重点梳理苍术燥性的相关研究,从苍术燥性表征指标、燥性标志物的研究技术、炮制对苍术燥性的影响及苍术燥性的应用挖掘进行了较为系统的总结和归纳。结果发现,苍术燥性表征主要包括饮水量、尿量、全血黏度和能量代谢等指标的上调,水液代谢指标的下调,以及颌下腺腺泡萎缩等病理变化;根据苍术炮制后的燥性与成分含量变化规律,确定苍术主要燥性成分可能为β-桉叶醇、苍术酮等挥发油类成分;苍术因其燥性,主要应用于治疗脾虚、风湿、水肿、泄泻等疾病。然而,目前对于苍术燥与效的关联性认识仍不足,对于其燥性的理解与解释还存在许多瓶颈,建议开展系统性评价和表征,以寻找苍术发挥燥与效的共性机制,为苍术的临床合理用药提供参考。Dryness is an important concept in the theory of traditional Chinese medicine,which is closely related to the transformation of the body,etiology and pathogenesis.As one of the medicinal properties of Chinese materia medica,there are various types of Chinese materia medica with dryness.Atractylodis Rhizoma(AR)is a representative medicine with warm and dry properties,which has the function of drying dampness and strengthening the spleen.Due to its strong dryness,it can cause certain adverse reactions.In clinical practice,stir-fried AR with bran is often used as medicine.The dryness of AR is closely related to its efficacy,but the underlying mechanism of the relationship between dryness and efficacy is still unclear.At present,the research on dryness Chinese materia medica has been increasing year by year,but there are still problems such as insufficient systematic research,insufficient in-depth research and lack of research on the mechanism of dryness effect,which limit the breakthrough of the theory of processing for slowing down dryness,and hinder the precise application of dryness Chinese materia medica in clinical practice.Therefore,this article comprehensively reviewed the differences in dryness characterization indicators of different Chinese materia medica by searching domestic and foreign literature,focusing on the relevant research on dryness of AR.A systematic summary and induction were made from the characterization indicators,research techniques of dryness markers,the influence of processing on dryness of AR,and the application mining of dryness of AR.The results showed that the dryness characteristics of AR mainly included the upregulation of macroscopic indicators such as water intake,urine output and whole blood viscosity,as well as energy metabolism indicators,the downregulation of water metabolism indicators,and pathological changes such as submandibular gland acinar atrophy.Based on the changes of dryness and component content of AR after processing,it is determined that the main dryness componen

关 键 词：苍术 燥性表征 中药炮制 质量标志物 麸炒品 Β-桉叶醇 苍术酮 

分 类 号：R22[医药卫生—中医基础理论] R943[医药卫生—中医学] R28[文化科学—图书馆学] G254