^(125)I放射性粒子植入联合局部3D-CRT治疗老年晚期非小细胞肺癌的临床效果与安全性  

Clinical Effect and Safety of ^(125)I Radioactive Seed Implantation Combined with Local 3D-CRT in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer

作　　者：成健 张超 周青青 CHENG Jian;ZHANG Chao;ZHOU Qingqing(Zouping People's Hospital, Zouping 256200, China;不详)

机构地区：[1]邹平市人民医院,山东邹平256200

出　　处：《中外医学研究》2024年第25期139-142,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨^(125)I放射性粒子植入联合局部三维适形放疗(3D-CRT)治疗老年晚期非小细胞肺癌(NSCLC)的临床效果与安全性。方法:选择2021年6月—2022年3月于邹平市人民医院肿瘤综合治疗中心首次就诊、经病理学确诊的52例老年晚期NSCLC患者作为研究对象,按照随机数表法将患者分为试验组和对照组,各26例。对照组采用3D-CRT治疗,试验组肺外周病灶在CT引导下行^(125)I放射性粒子植入,肺门及受累淋巴结区行3D-CRT治疗,比较两组近期疗效、不良反应发生情况。结果:试验组客观缓解率、疾病控制率分别为80.77%、88.46%,高于对照组的46.15%、57.69%,差异有统计学意义(P<0.05);试验组Ⅰ级、Ⅱ级放射性肺炎发生率低于对照组,差异有统计学意义(P<0.05);但两组Ⅰ级、Ⅱ级放射性食管炎、骨髓抑制、胃肠道反应发生率比较,差异无统计学意义(P>0.05)。结论:^(125)I放射性粒子植入联合局部3D-CRT治疗老年晚期NSCLC患者近期疗效显著,不良反应发生率低。Objective:To investigate the clinical effect and safety of ^(125)I radioactive seed implantation combined with local threedimensional conformal radiotherapy(3D-CRT)in the treatment of elderly patients with advanced non-small cell lung cancer(NSCLC).Method:A total of 52 elderly patients with advanced NSCLC who first diagnosed by pathology in the Comprehensive Cancer Treatment Center of Zouping People's Hospital from June 2021 to March 2022 were selected as the research objects,the patients were divided into the experimental group and the control group according to the random number table method,with 26 cases in each group.The control group was treated with 3D-CRT,and the experimental group was treated with CT-guided ^(125)I radioactive seed implantation in the peripheral lung lesions,and 3D-CRT was performed in the hilar and involved lymph node areas.The short-term efficacy and adverse reactions between two groups were compared.Result:The objective remission rate and disease control rate of the experimental group were 80.77% and 88.46%,respectively,which were higher than 46.15% and 57.69% of the control group,and the difference was statistically significant(P<0.05);the incidence of grade Ⅰ and grade Ⅱ radiation pneumonitis in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05);however,there were no significant differences in the incidence of grade Ⅰ and grade Ⅱ radiation esophagitis,bone marrow suppression and gastrointestinal reactions between two groups(P>0.05).Conclusion:125I radioactive seed implantation combined with local 3D-CRT has a significant short-term effect in the treatment of elderly patients with advanced NSCLC,and the incidence of adverse reactions is low.

关 键 词：晚期肺癌 ^(125)I 放射性粒子 适形放疗 

分 类 号：R734.2[医药卫生—肿瘤]