Selenoprotein-p and insulin resistance in children and adolescents with obesity  

作　　者：Amany Elbarky Kholoud Gamal Ismail Yousef Fouad Yousef Rasha Mohamed Gamal Elshafiey Radwa Mahmoud Elsharaby Asmaa El-Kaffas Mohammed Al-Beltagi 

机构地区：[1]Gastroenterology and Clinical Nutrition Unit,Pediatric Department,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [2]Department of Pediatric,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [3]Department of Clinical Pathology,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [4]Department of Paediatric,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Manama,Bahrain

出　　处：《World Journal of Clinical Pediatrics》2024年第3期40-52,共13页世界临床儿科杂志

摘　　要：BACKGROUND Insulin resistance and obesity present significant challenges in pediatric populations.Selenoprotein P1(SEPP1)serves as a biomarker for assessing selenium levels in the body.While its association with metabolic syndrome is established in adults,its relevance in children remains underexplored.AIM To ascertain SEPP1 blood levels in children and adolescents diagnosed with obesity and to assess its correlation with insulin resistance and adiposity indices.METHODS 170 children participated in this study,including 85 diagnosed with obesity and an equal number of healthy counterparts matched for age and sex.Each participant underwent a comprehensive medical evaluation,encompassing a detailed medical history,clinical examination,and anthropometric measurements like waist circumference and waist-to-height ratio.Furthermore,routine blood tests were conducted,including serum SEPP1,visceral adiposity index(VAI),and Homeostatic Model Assessment of Insulin Resistance(HOMA-IR)level.RESULTS Our findings revealed significantly lower serum SEPP1 levels in children with obesity compared to their healthy peers.Moreover,notable negative correlations were observed between serum SEPP1 levels and body mass index,VAI,and HOMA-IR.CONCLUSION The study suggests that SEPP1 could serve as a valuable predictor for insulin resistance among children and adolescents diagnosed with obesity.This highlights the potential utility of SEPP1 in pediatric metabolic health assessment and warrants further investigation.

关 键 词：OBESITY Childhood obesity Selenium status Selenoprotien P1 Insulin resistance 

分 类 号：R725.7[医药卫生—儿科]