Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds:A case report  

作　　者：Pei-Shen Zhang Rong Wang Hu-Wen Wu Han Zhou Han-Bin Deng Wen-Xuan Fan Jia-Cheng Li Shao-Wen Cheng 

机构地区：[1]Department of Wound Repair,Key Laboratory of Emergency and Trauma of Ministry of Education,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan Province,China

出　　处：《World Journal of Clinical Oncology》2024年第8期1110-1116,共7页世界临床肿瘤学杂志（英文版）

基　　金：Supported by Natural Science Foundation of Hainan Province,China,No.822MS174.

摘　　要：BACKGROUND Non-Hodgkin's lymphoma(NHL)is a malignant tumor that originates from the lymphoid tissues and can potentially affect numerous organs within the body.Among these,the skin stands out as one of the primary sites affected by NHL,often presenting with multiple extra-nodal manifestations.In this report,we present an unusual case of NHL involving chronic wounds in the lower extremities that were difficult to heal.The scars were successfully treated using radiotherapy in combination with extended excision debridement and peroneal artery perforator flap grafting,resulting in satisfactory outcomes.CASE SUMMARY A 19-year-old male patient presented with ulceration of the skin on the left calf near the ankle accompanied by purulent discharge.Subsequent pathologic biopsy confirmed a diagnosis of NHL(extranodal NK/T-cell lymphoma,nasal type).Initial treatment comprised local radiotherapy and wound care;however,the wound exhibited prolonged non-healing.Consequently,the patient underwent a series of interventions including radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap grafting.Ultimately,successful healing was achieved with favorable postoperative outcomes characterized by good texture of the flap without any signs of rupture or infection.CONCLUSION The combination of radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap grafting may present a favorable treatment modality for chronic non-healing lower leg wounds resulting from NHL.

关 键 词：Non-Hodgkin's lymphoma Extranodal natural killer/T-cell lymphoma Difficult-to-heal wounds Flap therapy Case report 

分 类 号：R733.4[医药卫生—肿瘤]