Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location  

作　　者：Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-Le Lin Jun-Yang Lu Lai Xu Guan-Nan Zhang Jun-Feng Du Bin Wu 

机构地区：[1]Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Medical Department of General Surgery,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Gastroenterology》2024年第33期3823-3836,共14页世界胃肠病学杂志（英文版）

基　　金：Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-003.

摘　　要：BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon cancer.However,the specific distinction between PIV of LCC and RCC remains unclear.AIM To investigate the prognostic and clinical significance of PIV in LCC and RCC patients.METHODS This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with RCC.We used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these patients.Kaplan-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for DFS.The correlation between PIV and the clinical characteristics was statistically analyzed in these patients.RESULTS A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were identified.PIV was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P<0.001].After propensity score matching,no difference in PIV was observed between patients with LCC and RCC[median(IQR):182.42(111.88-297.65)vs 189.45(109.44-316.02);P=0.987].PIV thresholds for DFS were 227.84 in LCC and 145.99 in RCC.High PIV(>227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;P<0.001]but not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC but not RCC,underscoring the importance of tumor location when using PIV as a colon cancer biomarker.

关 键 词：Colon cancer Left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis 

分 类 号：R735.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]