Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention  

作　　者：Matteo Micucci Bian-Zhao Xiang Chen-Min Ting Hiu-Yee Kwan Michele Mari Michele Retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli 

机构地区：[1]Department of Biomolecular Sciences,University of Urbino Carlo Bo,Urbino 61029,Italy [2]Hong Kong Chinese Medicine Clinical Study Centre,Chinese EQUATOR Centre,School of Chinese Medicine,Chinese Clinical Trial Registry(Hong Kong),Hong Kong Baptist University,Hong Kong 999077,China [3]Centre for Chinese Herbal Medicine Drug Development,Hong Kong Baptist University,Hong Kong 999077,China [4]Centre for Cancer and Inflammation Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 999077,China [5]Department of Chemistry,College of Science,Salahaddin University-Erbil,Erbil 44001,Iraq [6]Department of Pharmacognosy,Faculty Pharmacy,Tishk International University,Erbil 44001,Iraq [7]Institute of Oncology Research,Bellinzona CH6500,Switzerland [8]Universitàdella Svizzera Italiana,Lugano CH6900,Switzerland

出　　处：《World Journal of Gastrointestinal Oncology》2024年第9期3798-3819,共22页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and heterogeneous.This review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer prevention.Using advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical development.Focusing on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated compounds.These agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive strategies.The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework.This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention.The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关 键 词：Traditional Chinese medicine Precision medicine Molecular network PHYTOCHEMISTRY Food chemistry NUTRACEUTICALS Gastric cancer 

分 类 号：R730.59[医药卫生—肿瘤]