Correlation between non-alcoholic fatty liver disease and metabolic parameters in persons with newly diagnosed type 2 diabetes mellitus  

作　　者：Supriyo Mukherjee Sushmita Mukherjee Chun Shing Kwok Anne Phillips 

机构地区：[1]Department of Medicine,Research Centre for Diabetes Hypertension and Obesity,Samastipur 848101,India [2]Department of Clinical Ultrasonography,Research Centre for Diabetes Hypertension and Obesity,Samastipur 848101,India [3]Cardiology Registrar,University Hospitals of North Midlands NHS Trust United Kingdom,Staffordshire ST46QG,United Kingdom [4]Faculty of Health Education and Life Sciences,Department of Post-Qualifying Healthcare Practice,Birmingham City University,Birmingham B47AP,United Kingdom

出　　处：《World Journal of Hepatology》2024年第8期1120-1130,共11页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND There are limited studies investigating the association between type 2 diabetes mellitus(T2DM)and non-alcoholic fatty liver disease(NAFLD)in the region of Bihar,India.AIM To estimate the prevalence of NAFLD in persons with newly diagnosed T2DM in the population of North Bihar,India.METHODS This single centre cross-sectional study was undertaken in the Research Centre for Diabetes Hypertension and Obesity,Samastipur,Bihar,India.Data were collected from persons newly diagnosed with T2DM or those diagnosed within 6 months of when the study was conducted between December 2022 to May 2023.RESULTS A total of 148 people with newly diagnosed T2DM were included(median age 47 years,46.6%female)and 109 patients with liver disease on ultrasound evaluation.The persons with liver disease consumed more fats and oils(88.1%vs 74.4%,P=0.042)and they had significantly greater body mass index(27.4 vs 23.0,P<0.001),waist circumference(37 vs 33,P<0.001),and waist-to-hip ratio(1.00 vs 0.70,P=0.025).Females were associated with greater liver disease[odds ratio(OR):3.09,95%confidence interval(CI):1.09-8.80,P=0.32].Waist circumference(OR:1.42,95%CI:1.22-1.66,P<0.001)and low-density lipoprotein cholesterol(OR:1.01,95%CI:1.01-1.02,P=0.048)were associated with any liver disease.The factors most associated with grade 2/3 liver disease was right upper quadrant pain or heaviness(OR:5.22,95%CI:1.40-19.41,P=0.14),greater income(OR:3.58,95%CI:1.28-10.04,P=0.015)and waist circumference(OR:1.31,95%CI:1.02-1.69,P=0.036).CONCLUSION NAFLD is common in new/recently diagnosed T2DM and disease burden is high and common among patients who are either high consumers of fats and oils or have obesity-associated markers.

关 键 词：Type 2 diabetes mellitus Non-alcoholic fatty liver disease PREVALENCE Waist circumference OBESITY 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]