Dynamics of glutamine synthetase expression in hepatic ischemiareperfusion injury: Implications for therapeutic interventions  

作　　者：Zhi-Hao Huang Meng-Qi Dong Feng-Yong Liu Wei-Jie Zhou 

机构地区：[1]State Key Laboratory of Organ Failure Research,Department of General Surgery,Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of Interventional Radiology,Senior Department of Oncology,Fifth Medical Center of PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Hepatology》2024年第8期1177-1184,共8页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Hepatic ischemia-reperfusion injury(IRI)poses a great challenge in liver surgery and transplantation because of oxidative stress and inflammatory responses.The changes in glutamine synthetase(GS)expression during hepatic IRI remain unclear.AIM To investigate the dynamic expression of GS during hepatic IRI.METHODS Following hepatic ischemia for 1 h and reperfusion,liver tissue samples were collected at 0.5,6,and 24 hours postreperfusion for fixation,embedding,section-ing.Hematoxylin and eosin staining and GS staining were performed.RESULTS GS expression rapidly decreases in hepatocytes around the central vein after IRI,reaching its lowest point at 6 hours postreperfusion,and then gradually recovers.CONCLUSION GS is highly sensitive to IRI,highlighting its potential role as an indicator of liver injury states and a target for therapeutic intervention.

关 键 词：Hepatic ischemia-reperfusion Glutamine synthetase Central vein LIVER Injury repair 

分 类 号：R575[医药卫生—消化系统]