Miller fisher syndrome with positive anti-GQ1b/GT1a antibodies associated with COVID-19 infection:A case report  

作　　者：Cheng-Qun Wei Xuan Yu Yuan-Yuan Wu Qing-Jie Zhao 

机构地区：[1]Department of Neurology,Huai’an Hospital,Huai’an Cancer Hospital,Huai’an 223001,Jiangsu Province,China [2]Department of Neurology,The First Affiliated Hospital of Harbin Medical University,Harbin 150081,Heilongjiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第31期6500-6505,共6页世界临床病例杂志

摘　　要：BACKGROUND Miller fisher syndrome(MFS)is a variant of Guillain-Barrésyndrome,an acute immune-mediated peripheral neuropathy that is often secondary to viral infections.Anti-ganglioside antibodies play crucial roles in the development of MFS.The positive rate of ganglioside antibodies is exceptionally high in MFS patients,particularly for anti-GQ1b antibodies.However,the presence of other ganglioside antibodies does not exclude MFS.CASE SUMMARY We present a 56-year-old female patient who suddenly developed right blepharoptosis and progressively worsening vision in both eyes.There were flu symptoms prior to onset,and a coronavirus disease 2019 test was positive.On physical examination,the patient exhibited bilateral extraocular muscle paralysis,weakened reflexes in both limbs,and impaired coordination.The cerebrospinal fluid examination results showed no obvious abnormalities.Bilateral peroneal nerve F-waves were not extracted.Serum anti-GD1b IgG and anti-GT1a IgG antibodies were positive.The patient received intravenous methylprednisolone(1000 mg/day),with the dosage gradually decreased.Additionally,intravenous high-dose immunoglobulin treatment was administered for 5 days(0.4 g/kg/day)from day 2 to day 6 of hospitalization.The patient’s symptoms improved after treatment with immunoglobulins and hormones.CONCLUSION Positive ganglioside antibodies may be used as supporting evidence for the diagnosis;however,the diagnosis of MFS is more reliant on clinical symptoms.

关 键 词：Miller fisher syndrome Guillain-Barre syndrome COVID-19 Anti-GQ1b antibody Anti-GT1a antibody Case report 

分 类 号：R739.4[医药卫生—肿瘤]