Anti-inflammatory effects of Tao Hong Si Wu Tang in mice with lung cancer and chronic obstructive pulmonary disease  

作　　者：Guo-Li Wang Yan-Ling Xu Ke-Ming Zhao Ai-Feng Sui Li-Na Wang Hu Deng Ge Wang 

机构地区：[1]First Department of Respiratory and Critical Care Medicine/Pulmonary Disease,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,Liaoning Province,China [2]Second Department of Respiratory and Critical Care Medicine/Pulmonary Disease,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,Liaoning Province,China [3]Department of Spleen and Stomach Oncology,The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110101,Liaoning Province,China

出　　处：《World Journal of Clinical Oncology》2024年第9期1198-1206,共9页世界临床肿瘤学杂志（英文版）

基　　金：Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.

摘　　要：BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammat

关 键 词：Tao Hong Si Wu Tang Anti-inflammatory Chronic obstructive pulmonary disease Lung cancer Traditional Chinese medicine 

分 类 号：R734.2[医药卫生—肿瘤]