Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1:A case report  

作　　者：Xiao-Yu Zhang Jian-Fa Yu Yang Li Ping Li 

机构地区：[1]The First Central Hospital Clinical School,Tianjin Medical University,Tianjin 300192,China [2]Department of Hepatobiliary Surgery,Tianjin First Central Hospital,School of Medicine,Nankai University,Tianjin 300192,China [3]Clinical School of the Second People’s Hospital,Tianjin Medical University,Tianjin 300192,China [4]Department of Hepatology,Tianjin Second People’s Hospital,Tianjin 300192,China

出　　处：《World Journal of Clinical Oncology》2024年第9期1222-1231,共10页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Patients with neurofibromatosis type 1(NF1)are exposed to a higher risk of developing neuroendocrine tumors(NETs).Periampullary neuroendocrine neoplasms(NENs)in NF1 patients primarily affect the duodenum and periampullary region.CASE SUMMARY A 50-year-old male patient was admitted to our hospital due to progressive skin and scleral yellowing for over 6 months.An abdominal contrast-enhanced computed tomography scan revealed a tumor in the periampullary region,which measured 1.2 cm×1.4 cm in size and showed a progressive enhancement.Magnetic resonance cholangiopancreatography indicated the dilation of intrahepatic and extrahepatic bile ducts.The patient was diagnosed with an ampullary tumor with the possibility of malignancy.A Whipple procedure was performed.Microscopically,the duodenum tumor was found to invade the mucosa,sphincter,and muscular layer of the duodenal papilla.Histologic hematoxylin and eosin staining confirmed the presence of duodenal G1 NET.Subsequently,a bibliometric analysis was performed to evaluate the state of NEN research.Publications about periampullary NENs showed an annual increase,with most of them focusing on the treatment and diagnosis of NENs.CONCLUSION This article reported a case of periampullary duodenal NET in a patient with NF1,and a bibliometric analysis was conducted.

关 键 词：Neuroendocrine tumor Neurofibromatosis-1 Endocrine carcinoma Bibliometric analysis Case report 

分 类 号：R735.7[医药卫生—肿瘤]