MicroRNA-630:A potential guardian against inflammation in diabetic kidney disease  

作　　者：Ashraf Al Madhoun 

机构地区：[1]Department of Genetics and Bioinformatics,Dasman Diabetes Institute,Dasman 15400,Kuwait

出　　处：《World Journal of Diabetes》2024年第9期1837-1841,共5页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Kuwait Foundation for the Advancement of Sciences and Dasman Diabetes Institute,Kuwait,No.RACB-2021-007.

摘　　要：In this editorial,we comment on the article by Wu et al published“MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4”.Diabetic kidney disease(DKD)stands as a significant complication occurring from diabetes mellitus,which contributes substantially to the morbidity and mortality rates worldwide.Renal tubular epithelial cell damage,often accompanied by inflammatory responses and mesenchymal transdifferentiation,plays a pivotal role in the progression of DKD.Despite extensive research,the intricate molecular mechanisms underlying these processes remain to be determined.Wu et al remarkable work identifies microRNA-630(miR-630)as an emerging potential regulator of cell migration,apoptosis,and autophagy,prompting investigation into its association with DKD pathogenesis.This study endeavors to elucidate the impact of miR-630 on TEC injury and the inflammatory response in DKD rats.The role of miR-630 in human DKD will be of interest for future studies.

关 键 词：Diabetic kidney disease MICRORNA MicroRNA-630 Toll-like receptor 4 INFLAMMATION 

分 类 号：R725.8[医药卫生—儿科] R726.9[医药卫生—临床医学]