Circular RNA: The evolving potential in the disease world  

作　　者：Aarti Sharma Cherry Bansal Kiran Lata Sharma Ashok Kumar 

机构地区：[1]Department of Research,Mayo Clinic Arizona,Phoenix,AZ 85054,United States [2]Department of Pathology,Dr.S Tantia Medical College,Hospital and Research Center,Sri Ganganagar 335002,Rajasthan,India [3]Department of Pathology,Baylor College of Medicine,Houston,TX 77030,United States [4]Department of Surgical Gastroenterology,Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow 226014,Uttar Pradesh,India

出　　处：《World Journal of Medical Genetics》2024年第1期1-16,共16页世界医学遗传学杂志

摘　　要：Circular RNAs(circRNAs),a new star of noncoding RNAs,are a group of endogenous RNAs that form a covalently closed circle and occur widely in the mammalian genome.Most circRNAs are conserved throughout species and fre-quently show stage-specific expression during various stages of tissue develop-ment.CircRNAs were a mystery discovery,as they were initially believed to be a product of splicing errors;however,subsequent research has shown that ci-rcRNAs can perform various functions and help in the regulation of splicing and transcription,including playing a role as microRNA(miRNA)sponges.With the application of high throughput next-generation technologies,circRNA hotspots were discovered.There are emerging indications that explain the association of circRNAs with human diseases,like cancers,developmental disorders,and in-flammation,and circRNAs may be a new potential biomarker for the diagnosis and treatment outcome of various diseases,including cancer.After the discoveries of miRNAs and long noncoding RNAs,circRNAs are now acting as a novel re-search entity of interest in the field of RNA disease biology.In this review,we aim to focus on major updates on the biogeny and metabolism of circRNAs,along with their possible/established roles in major human diseases.

关 键 词：Circular RNAs Cancer MicroRNA sponges Biomarkers Long noncoding RNA RNA biology 

分 类 号：R394[医药卫生—医学遗传学]