Analysis of alkaline phosphatase and γ-glutamyltransferase after radiofrequency ablation of primary liver cancer: A retrospective study  

作　　者：Wen-Yu Huang Sheng Zheng Dan Zhu Ying-Lang Zeng Juan Yang Xue-Li Zeng Pei Liu Shun-Ling Zhang Ming Yuan Zhi-Xia Wang 

机构地区：[1]Department of Tumor and Vascular Interventional Therapy,Xiamen Humanity Hospital,Xiamen 361000,Fujian Province,China [2]Department of Gastroenterology,The Third People's Hospital of Yunnan Province,Kunming 650011,Yunnan Province,China [3]Medical Imaging Center,Qian Wei Hospital of Jilin Province,Changchun 130000,Jilin Province,China [4]Department of Science and Education,The Third People's Hospital of Yunnan Province,Kunming 650011,Yunnan Province,China [5]Graduate School of Clinical Medicine,Dali University,Dali 671000,Yunnan Province,China [6]Department of Hepatobiliary Surgery,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China [7]Department of Oncology,The Affiliated Shuyang Hospital of Xuzhou Medical University,Suqian 223600,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第9期2860-2869,共10页世界胃肠外科杂志（英文版）（电子版）

基　　金：Yunnan Province High-level Scientific and Technological Talents and Innovation Team Selection Special,No.202405AC350067;Basic Research Joint Special General Project of Yunnan Provincial Local Universities(Part),No.202301BA070001-029 and No.202301BA070001-044;Scientific Research Fund Project of Education Department of Yunnan Province,No.2023J0926;The 8th Research Project of Education and Teaching Reform of Dali University(Special Medical Education Reform Project),No.2022JGYX08-01 and No.2022JGYX08-02.

摘　　要：BACKGROUND Changes in alkaline phosphatase(ALP)andγ-glutamyltransferase(GGT)levels in patients with primary liver cancer(PLC)after radiofrequency ablation(RFA).Hepatocellular carcinoma is a malignant tumor with high incidence worldwide.As a common local treatment,RFA has attracted much attention for its efficacy and influence on liver function.AIM To investigate the effect of serum ALP and GGT levels on the prognosis of patients with PLC treated by RFA.METHODS The preoperative clinical data of 165 patients who were pathologically or clinically diagnosed with PLC and who received RFA in our hospital between October 2018 and June 2023 were collected.The chi-square test was used to compare the data between groups.The Kaplan-Meier method and Cox regression were used to analyze the associ-ations between serum ALP and GGT levels and overall survival,progression-free survival(PFS)and clinical characteristics of patients before treatment.RESULTS The 1-year survival rates of patients with normal(≤135 U/L)and abnormal(>135 U/L)serum ALP before treatment were 91%and 79%,respectively;the 2-year survival rates were 90%and 68%,respectively;and the 5-year survival rates were 35%and 18%,respectively.The difference between the two groups was statistically significant(P=0.01).Before treatment,the 1-year survival rates of patients with normal serum GGT levels(≤45 U/L)and abnormal serum GGT levels(>45 U/L)were 95%and 87%,the 2-year survival rates were 85%and 71%,and the 5-year survival rates were 37%and 21%,respectively.The difference between the two groups was statist-ically significant(P<0.001).Serum ALP[hazard ratio(HR)=1.766,95%confidence interval(95%CI):1.068-2.921,P=0.027]and GGT(HR=2.312,95%CI:1.367-3.912,P=0.002)is closely related to the overall survival of PLC patients after RF ablation and is an independent prognostic factor.The 1-year PFS rates were 72%and 50%,the 2-year PFS rates were 52%and 21%,and the 5-year PFS rates were 14%and 3%,respectively.The difference between the two groups was statistically significant(P

关 键 词：Alkaline phosphatase γ-glutamyltransferase Radiofrequency ablation Primary liver cancer Retrospective study 

分 类 号：R735.7[医药卫生—肿瘤]