Preoperative systemic inflammatory response index as a prognostic marker for distal cholangiocarcinoma after pancreatoduodenectomy  

作　　者：Wen-Hui Zhang Yu Zhao Cheng-Run Zhang Jin-Can Huang Shao-Cheng Lyu Ren Lang 

机构地区：[1]Department of Hepatobiliary Surgery,Beijing Chao-Yang Hospital Affiliated to Capital Medical University,Beijing 100020,China [2]Department of Urology Surgery,Beijing Chao-Yang Hospital Affiliated to Capital Medical University,Beijing 100020,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第9期2910-2924,共15页世界胃肠外科杂志（英文版）（电子版）

基　　金：the Beijing Natural Science Foundation,No.7222303.

摘　　要：BACKGROUND The relationship between preoperative inflammation status and tumorigenesis as well as tumor progression is widely acknowledged.AIM To assess the prognostic significance of preoperative inflammatory biomarkers in patients with distal cholangiocarcinoma(dCCA)who underwent pancreat-oduodenectomy(PD).METHODS This single-center study included 216 patients with dCCA after PD between January 1,2011,and December 31,2022.The individuals were categorized into two sets based on their systemic inflammatory response index(SIRI)levels:A low SIRI group(SIRI<1.5,n=123)and a high SIRI group(SIRI≥1.5,n=93).Inflam-matory biomarkers were evaluated for predictive accuracy using receiver operating characteristic curves.Both univariate and multivariate Cox proportional hazards analyses were performed to estimate SIRI for overall survival(OS)and recurrence-free survival(RFS).RESULTS The study included a total of 216 patients,with 58.3%being male and a mean age of 65.6±9.6 years.123 patients were in the low SIRI group and 93 were in the high SIRI group after PD for dCCA.SIRI had an area under the curve value of 0.674 for diagnosing dCCA,showing better performance than other inflammatory biomarkers.Multivariate analysis indicated that having a SIRI greater than 1.5 independently increased the risk of dCCA following PD,leading to lower OS[hazard ratios(HR)=1.868,P=0.006]and RFS(HR=0.949,P<0.001).Additionally,survival analysis indicated a significantly better prognosis for patients in the low SIRI group(P<0.001).CONCLUSION It is determined that a high SIRI before surgery is a significant risk factor for dCCA after PD.

关 键 词：Distal cholangiocarcinoma PANCREATODUODENECTOMY BIOMARKER Systemic inflammatory response index Prognosis 

分 类 号：R657.5[医药卫生—外科学]