Role of long non-coding RNAs in non-alcoholic fatty liver disease  

作　　者：Anju Mullath Murali Krishna 

机构地区：[1]Department of Gastroenterology,Aster Royal Hospital,Muscat 133,Muscat,Oman [2]Department of Urology,Army Hospital,R&R,Delhi Cantonment 110010,Delhi,India

出　　处：《World Journal of Meta-Analysis》2024年第3期1-5,共5页世界荟萃分析杂志

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is emerging as a common cause of chronic liver disease in children and adults.NAFLD can progress to steatohepa-titis and potentially even hepatocellular carcinoma.Early identification of pati-ents at risk for progressive disease is crucial for managing NAFLD.Recent studies have identified long noncoding RNAs(lncRNAs),circular RNAs,and microRNAs as playing important roles in the pathogenesis of NAFLD.These noncoding RNAs are involved in modulating several metabolic pathways such as hepatic glucose and lipid metabolism,oxidative stress,and even carcinogenesis.Elevated levels of lncARSR and lncRNA nuclear-enriched abundant transcript 1 have been found in patients with NAFLD.In addition,lncRNAs such as PRYP4-3 and RP11-128N14.5 can distinguish patients with NAFLD from healthy indi-viduals.Increased MEG3 expression has been observed in both NAFLD and non-alcoholic steatohepatitis,suggesting that it may help predict patients at risk for disease progression.With advances in transcriptomics,we may discover additional targets to help in the identification and prognostication of NAFLD.

关 键 词：Long noncoding RNA Non-alcoholic fatty liver disease Plasmacytoma variant translocation 1 Nuclear-enriched abundant transcript 1 Muscle-and adiposeassociated long intergenic non-coding RNA H19 

分 类 号：R575[医药卫生—消化系统]