Retrospective study evaluating association of colorectal tumors and hepatitis C virus  

作　　者：Maya Gogtay Lekha Yadukumar Yuvaraj Singh Mithil Gowda Suresh Aakriti Soni Anuroop Yekula Asha Bullappa George M Abraham 

机构地区：[1]Department of Hematology and Oncology,Internal Medicine,University of Nebraska Medical Center,Omaha,NE 68198,United States [2]Department of Internal Medicine,The Wright Center for Graduate Medical Education,Scranton,PA 18505,United States [3]Department of Gastroenterology and Hepatology,University of Massachusetts Chan Medical School,Worcester,MA 01605,United States [4]Department of Internal Medicine,Saint Vincent Hospital,Worcester,MA 01608,United States [5]Department of Internal Medicine,St.Vincent Hospital,Worcester,MA 01608,United States [6]Department of Community Medicine,SS Institute of Medical Sciences and Research Centre,Davangere 577003,Karnataka,India

出　　处：《World Journal of Virology》2024年第3期56-64,共9页世界病毒学杂志

摘　　要：BACKGROUND Chronic hepatitis C virus(HCV)has been associated with hepatic and extrahe-patic malignancies.Limited studies have shown an association between colorectal adenomas and HCV populations.AIM To study the prevalence of colorectal adenomas in patients with HCV compared to the general population and to evaluate if it is an independent risk factor for colorectal adenomas.METHODS Patients were divided into HCV and non-HCV based on their HCV RNA titers.Patients with alcoholic liver disease,hepatitis B infection,and inflammatory bowel disease were excluded.Continuous variables were analyzed using the Mann-Whitney U test,and categorical variables usingχ^(2) with P<0.05 were considered statistically significant.The significant covariates(independent variables)were matched in both groups by propensity score matching,followed by multivariate regression analysis.RESULTS Of the 415 patients screened,109 HCV patients and 97 non-HCV patients with colonoscopy results were included in the study.HCV patients were older,had a smoking history,had less frequent aspirin use,and had a lower body mass index(BMI)(P<0.05).The HCV cohort had a significantly increased number of patients with adenomas(adenoma detection rate of 53.2%vs 34%.P=0.006).We performed a propensity-matched multivariate analysis where HCV infection was significantly associated with colorectal adenoma(OR:2.070,P=0.019).CONCLUSION Our study shows a significantly higher rate of adenomas in HCV patients compared to the general population.Prospective studies would help determine if the increase in adenoma detection lowers the risk for colorectal cancer.

关 键 词：Hepatitis C Colon cancer ADENOMA POLYPS COLONOSCOPY 

分 类 号：R735.37[医药卫生—肿瘤] R563.1[医药卫生—临床医学]