Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin  

作　　者：Yue Zhou Hui Xu Ka-Wing Cheng Feng Chen Qian Zhou Mingfu Wang 

机构地区：[1]College of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518060,China

出　　处：《Food Science and Human Wellness》2024年第5期2584-2594,共11页食品科学与人类健康（英文）

基　　金：supported by the National Key R&D Program of China(2021YFD2100103);the National Natural Science Foundation of China(32101935).

摘　　要：Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs.Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure.In human umbilical vein endothelial cells(HUVECs),we found that glycidol treatment promoted endothelialto-mesenchymal transition(EndMT)at a lower concentration(0.5 mmol/L),while induced apoptosis and inflammation at a higher concentration(1 mmol/L).These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species(ROS).In addition,the protective potential of 6-C-(E-2-fluorostyryl)naringenin(6-CEFN)against glycidol was evaluated and compared with naringenin.HUVECs pre-treated with 6-CEFN,but not naringenin,displayed resistance to endothelial dysfunction caused by glycidol.

关 键 词：GLYCIDOL Endothelial cells 6-C-(E-2-fluorostyryl)naringenin Oxidative stress Endothelial-to-mesenchymal transition 

分 类 号：TS201.4[轻工技术与工程—食品科学]