甲状腺癌分子标志物及其在临床诊疗中的应用进展  

Thyroid carcinoma biomarkers and its application in clinical diagnosis and treatment:recent progress

作　　者：滕伟强 王秋阳 马毅 张才云[1] 郑宏良[1] 朱乘婧 刘济生[2] TENG Weiqiang;WANG Qiuyang;MA Yi;ZHANG Caiyun;ZHENG Hongliang;ZHU Chengjing;LIU Jisheng(Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Naval Medical University(Second Military Medical niversity),Shanghai 200433,China;Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院耳鼻咽喉头颈外科,上海200433 [2]苏州大学第一附属医院耳鼻咽喉头颈外科,苏州215000

出　　处：《海军军医大学学报》2024年第9期1127-1133,共7页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81970868,81972537,81200734)。

摘　　要：甲状腺癌发病与环境因素密切相关,环境变化导致的基因突变和腺体组织分子生物学改变是诱发甲状腺癌的重要因素之一。尽管甲状腺癌的相关分子机制仍未完全阐明,但随着分子生物学技术的发展,越来越多的甲状腺癌特定遗传改变和分子标志物被挖掘出来。本文就甲状腺癌的病因、特异性分子标志物、诊断及靶向治疗研究进展进行综述,为甲状腺癌的临床诊疗提供理论支持。Thyroid carcinoma is closely related to environmental factors.Gene mutations and molecular biological changes of gland tissue caused by environmental changes are important factors inducing thyroid carcinoma.Although the molecular mechanism of thyroid carcinoma has not been fully elucidated,increasingly specific genetic changes and molecular markers for thyroid carcinoma have been discovered with the development of molecular biology techniques.This article reviews the recent progresses on the etiology,specific molecular markers,diagnosis and targeted therapies of thyroid carcinoma,so as to provide theoretical support for the clinical diagnosis and treatment of thyroid carcinoma.

关 键 词：甲状腺肿瘤 分子机制 分子标志物 癌基因 基因突变 基因重排 

分 类 号：R736.1[医药卫生—肿瘤]