基于纳米复合材料修饰微针的pH值实时检测电化学生物传感器  

Electrochemical biosensor based on nanocomposites-modified microneedle for real-time monitoring of pH value

作　　者：明涛 兰婷婷 于明星 孔德领[1] Ming Tao;Lan Tingting;Yu Mingxing;Kong Deling(Institute of Transplantation Medicine,Nankai University,Tianjin 300190,China)

机构地区：[1]南开大学移植医学研究院,天津300071

出　　处：《现代仪器与医疗》2024年第4期16-20,共5页Modern Instruments & Medical Treatment

基　　金：国家重大科研仪器研制项目(82127808)。

摘　　要：为了更好的监控人体生理状态,本文提出了一种基于纳米复合材料修饰微针的生物传感器研制策略。通过精巧设计与高性能纳米功能膜的构建,基于不锈钢针与金丝微针基底研制了两种各具优势的pH值实时检测传感器,实现了对pH值的实时检测。结果表明,生物传感器具有毫伏级输出电压,响应时间在秒级。综上,本文所提出的纳米微针生物传感器具有高灵敏,微创,响应迅速和结构简单的优点,可以有效地实现对pH的实时检测。To better monitor the physiological state of the human body,this paper proposes a biosensor development strategy based on nanocomposite-modified microneedles.Through sophisticated design and the construction of high-performance nanomembranes,two pH real-time monitoring sensors with distinct advantages were developed using stainless steel needles and gold wire microneedles,achieving real-time pH detection.The results indicate that the biosensor produces a millivolt output voltage and has a response time of just a few seconds.In summary,the nanomaterial-modifi ed microneedle biosensor proposed in this paper of fers high sensitivity,minimal invasiveness,rapid response,and simple structure,ef fectively enabling real-time pH monitoring.

关 键 词：实时检测 生物传感器 微创探针 纳米材料 电化学1 

分 类 号：TH142[一般工业技术—材料科学与工程] O657.1[机械工程—机械制造及自动化]