铁死亡:肿瘤放疗增敏新机遇  

Ferroptosis:new opportunities for radiosensitization

作　　者：沈自强 孙逸初 梁飞 杨晶 周冲[3] 夏铀铀[1] Shen Ziqiang;Sun Yichu;Liang Fei;Yang Jing;Zhou Chong;Xia Youyou(Department of Radiotherapy,Lianyungang Clinical College of Nanjing Medical University/The First People's Hospital of Lianyungang,Lianyungang 222000,China;Department of Radiotherapy,The Afiliated Lianyungang Hospital of Xuzhou Medical University/The First People's Hospital of Lianyungang,Lianyungang 222000,China;Department of Radiotherapy,Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]南京医科大学连云港临床医学院(连云港市第一人民医院)放疗科,连云港222000 [2]徐州医科大学附属连云港医院(连云港市第一人民医院)放疗科,连云港222000 [3]徐州市中心医院放疗科,徐州221000

出　　处：《中华放射肿瘤学杂志》2024年第9期864-869,共6页Chinese Journal of Radiation Oncology

基　　金：吴阶平医学基金临床科研项目(320.6750.2020-10-73);江苏省连云港市科技计划项目(SF2347);江苏省高校重点实验室开放研究课题项目(XZSYSKF2022042)。

摘　　要：铁死亡是近年来发现的一种新型的细胞死亡形式,表现为铁依赖性的、以多不饱和脂肪酸磷脂过氧化为特征的细胞死亡.最近研究发现,放射治疗可以通过电离辐射诱导肿瘤细胞发生铁死亡,放疗联合小分子或纳米铁死亡诱导剂可以抑制肿瘤生长并增强放疗敏感性.本文就铁死亡的机制以及放疗诱导铁死亡的通路进行综述,并探讨小分子药物和纳米材料介导铁死亡在放疗增敏中的潜在应用前景.Ferroptosis is a novel form of cell death discovered in recent years,characterized by iron-dependent cell death featuring the peroxidation of polyunsaturated fatty acid phospholipids.Recent studies have found that radiotherapy can induce ferroptosis in tumor cells through ionizing radiation,and the combination of radiotherapy with small molecule or nano-scale ferroptosis inducers can inhibit tumor growth and enhance radiosensitization.This review summarizes the mechanisms of ferroptosis and the pathways through which radiotherapy induces ferroptosis,and also explores the potential application prospects of small molecule drugs and nanomaterials in mediating ferroptosis for the radiosensitization of tumor treatment.

关 键 词：放射疗法 铁死亡 纳米药物 肿瘤 

分 类 号：R730.55[医药卫生—肿瘤]