CYP2C19基因多态性与难治性精神分裂症的关系  

Association between CYP2C19 gene polymorphisms and refractory schizophrenia

作　　者：王明[1] 杜向东 潘惠[1] 杨忠[1] WANG Ming;DU Xiangdong;PAN Hui(Department of Mood Disorders,Changshu Third People's Hospital,Changshu 215501,China)

机构地区：[1]常熟市第三人民医院,常熟215501 [2]苏州市广济医院

出　　处：《国际精神病学杂志》2024年第4期1046-1048,共3页Journal Of International Psychiatry

基　　金：常熟市卫生健康委员会医学科技项目(编号:CSWS201806)。

摘　　要：目的探讨细胞色素P450家族成员2C19(CYP2C19)基因多态性与难治性精神分裂症的关系。方法选取108例难治性精神分裂症患者,90例非难治性精神分裂症患者,分别记为难治组和非难治组。检测CYP2C19基因多态性,并分为广泛代谢型(EM),中间代谢型(IM)和慢代谢型(PM)。对比难治组和非难治组患者临床资料和CYP2C19基因多态性代谢情况。Logistic回归分析影响难治性精神分裂症的相关因素。结果难治组病程,简明精神科量表(BPRS)评分,阳性和阴性症状量表(PANSS)评分,临床大体印象量表严重程度量表(CGI-S)评分及泌乳素(Prolactin,PRL)水平高于非难治组(P<0.05),CYP2C19基因EM占比低于非难治组(P<0.05),IM,PM占比则高于非难治组(P<0.05)。多因素分析结果显示:CGI-S评分,PRL,CYP2C19基因为IM/PM均为难治性精神分裂症的危险因素(P<0.05)。结论CYP2C19基因多态性与精神分裂症难治性相关,IM,PM型精神分裂症难治性的风险较高。Objective To investigate the relationship between 2C19(CYP2C19)gene polymorphism in cytochrome P450 family members and refractory schizophrenia.Methods 108 patients with refractory schizophrenia and 90 patients with non-refractory schizophrenia were selected and recorded respectively in the refractory group and nonrefractory group.The polymorphism of CYP2C19 gene was detected and classified into broad metabolizer(EM),intermediate metabolizer(IM)and slow metabolizer(PM).Clinical data and polymorphism of CYP2C19 gene were compared between refractory group and refractory group.Logistic regression analysis of the related factors affecting refractory schizophrenia.Results The course of disease,Concise Psychiatric Scale(BPRS)score,Positive and Negative Symptom Scale(PANSS)score,Clinical Gross Impression Scale Severity Scale(CGI-S)score and Prolactin(PRL)level in refractory group were higher than those in refractory group(P<0.05).The proportion of EM in CYP2C19 gene was lower than that in non-refractory group(P<0.05),while the proportion of IM and PM was higher than that in nonrefractory group(P<0.05).Multifactor analysis showed that CGI-S score,PRL and CYP2C19 gene IM/PM were all risk factors for refractory schizophrenia(P<0.05).Conclusion CYP2C19 gene polymorphism is associated with refractory schizophrenia,and the risk of refractory schizophrenia is higher in IM and PM types.

关 键 词：精神分裂症 难治性 细胞色素P450家族成员2C19 基因多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]