广州市住院精神分裂症及双相障碍患者生活质量保护因素分析  

Protective factors of quality of life in inpatients with schizophrenia and bipolar disorder in Guangzhou

作　　者：徐璇钰 苏敬华[1,2,3] 胡应基 陈夕圆 陈晓东 XU Xuanyu;SU Jinghua;HU Yingji(The Affiliated brain hospital of Guangzhou Medical University,Guangzhou 510370,China)

机构地区：[1]广州医科大学附属脑科医院,广州510370 [2]广东省神经科学疾病研究重点实验室 [3]神经致病基因与离子通道病省部共建重点实验室

出　　处：《国际精神病学杂志》2024年第4期1061-1068,共8页Journal Of International Psychiatry

基　　金：广东省医学科学技术研究基金项目(编号:A2022381;B2021185)。

摘　　要：目的探讨住院双相障碍及精神分裂症患者生活质量水平的保护性因素。方法在广州市4家精神科住院部连续入组符合《国际疾病分类(第10版)》(ICD-10)双相障碍或精神分裂症诊断标准的患者465例,采用自编人口学及临床特征问卷调查患者人口学及临床特征并进行分类,采用世界卫生组织生活质量测定量表简表(WHOQOL-BREF)评估患者生活质量,分析不同社会人口学及临床特征分类患者生活质量差异,采用多元方差分析患者生活质量的保护因素。结果共465名患者符合入组标准,四所医院患者生理领域评分(58.15±15.65),心理领域评分(49.13±8.20),社会关系领域评分(48.78±15.83),环境领域评分(51.48±14.44),均低于中国常模标准(P<0.05)。在睡眠时长,运动情况,年龄,有无合并躯体慢性病,性别,婚姻状况,自知力水平,病程,吸烟情况上表现出显著差异(P<0.05)。在文化程度,体重状态,起病年龄,饮酒情况上无显著差异,均P>0.05。多元方差分析结果显示,男性,曾经结婚或同居,自知力水平高,睡眠时长>7小时,规律运动是患者生活质量的保护因素(P<0.05);性别*自知力水平,婚姻状况*睡眠时长*运动情况,婚姻状况*自知力水平*睡眠时长*运动情况,性别*婚姻状况*自知力水平*运动情况对患者生活质量存在交互作用影响。结论住院精神分裂症及双相障碍患者生活质量水平和多种人口学特征及临床特征相关,应根据相关特点进行有针对性干预,从而提高患者生活质量,促进全面康复。Objective To explore the protective factors of quality of life(QOL)in hospitalized patients with bipolar disorder or schizophrenia.Methods A total of 465 patients with bipolar disorder or schizophrenia who met the diagnostic criteria of the International Classification of Diseases(10th edition)(ICD-10)were continuously enrolled in four psychiatric inpatient departments in Guangzhou.The demographic and clinical characteristics of the patients were investigated and classified by self-designed questionnaire,the quality of life(QOL)was assessed with the World Health Organization Short Form for quality of life(WHOQOL-BREF),and the differences of QOL among different socio-demographic and clinical categories were analyzed,multivariate analysis of variance was used to analyze the protective factors of patients'quality of life.Results A total of 464 patients met the inclusion criteria.The scores of patients in four hospitals were 58.15±15.65 in physiological domain,49.13±8.20 in psychological domain,48.78±15.83 in social relationship domain and 51.48±14.44 in environmental domain,it was lower than Chinese norm standard(P<0.05).There were significant differences in sleep duration,exercise,age,physical chronic disease,sex,marital status,insight level,course of disease and smoking(P<0.05).There was no significant difference in education,weight,age of onset and drinking(P>0.05).The results of multivariate analysis of variance showed that male,having been married or cohabiting,high insight level,sleeping longer than 7 hours and regular exercise were the protective factors of quality of life(P<0.05).Gender*Insight Level,marital status*sleep duration*exercise status,marital status*Insight Level*sleep duration*exercise status,gender*marital status*Insight Level*exercise status had an interactive effect on patients'quality of life.Conclusion The QOL of hospitalized patients with schizophrenia and bipolar disorder is correlated with a variety of demographic and clinical characteristics,so targeted intervention should be carried

关 键 词：生活质量 精神分裂症 双相障碍 睡眠 运动 

分 类 号：R749.3[医药卫生—神经病学与精神病学]