齐拉西酮联合改良电休克治疗首发精神分裂症患者疗效及对攻击行为,认知功能的影响  

Therapeutic effect of ziprasidone combined with modified electroconvulsive therapy on patients with first-episode schizophrenia and the impact on aggressive behavior and cognitive function

作　　者：张富超 续慧蕾 梁丽君 陈丽 廖静 ZHANG Fuchao;XU Huilei;LIANG Lijun(Department of Psychiatry,Nanchong Physical and Mental Hospital,Nanchong 637000,China)

机构地区：[1]南充市身心医院精神科,南充637000

出　　处：《国际精神病学杂志》2024年第4期1087-1090,共4页Journal Of International Psychiatry

摘　　要：目的观察齐拉西酮联合改良电休克(modified electroconvulsive therapy,MECT)对首发精神分裂症疗效,攻击行为和认知功能的影响。方法选取2021年1月~2022年2月我院收治的100例精神分裂症患者,随机纳为观察组与对照组,各50例,其中对照组给予齐拉西酮治疗,观察组在此基础上联合MECT治疗。比较两组疗效,外显攻击行为量表(modified overt aggression scale,MOAS),阳性与阴性症状量表(positive and negative symptom scale,PANSS),蒙特利尔认知量表(Montreal cognitive assessment,MoCA)及简易智能精神量表(mini-mental state examination,MMSE)评分。结果治疗4周后观察组疗效总有效率为92.00%,高于对照组的76.00%(P<0.05)。治疗4周后,观察组MOAS,PANSS评分较对照组低(P<0.05);MoCA,MMSE评分较对照组高(P<0.05)。治疗期间两组不良反应发生率无明显差异(P>0.05)。结论齐拉西酮联合MECT治疗精神分裂症疗效肯定,有助于改善患者症状,攻击行为及认知功能,安全性高。Objective To observe the effects of ziprasidone combined with modified electroconvulsive therapy(MECT)on therapeutic effect,aggressive behavior,and cognitive function in patients with first-episode schizophrenia.Methods One hundred patients with first-episode schizophrenia admitted to the hospital from January 2021 to February 2022 were selected and randomly divided into the observation group and the control group,with 50 cases in each group.The control group was treated with ziprasidone,and the observation group was treated with MECT on this basis.The two groups were compared in terms of therapeutic effects,the Modified Overt Aggression Scale(MOAS)scores,the Positive and Negative Syndrome Scale(PANSS)scores,the Montreal Cognitive Assessment Scale(MoCA)scores,the Mini Mental State and Examination Scale(MMSE)scores.Results After 4 weeks of treatment,the total effective rate of the observation group(92.00%)was higher than that of the control group(76.00%)(P<0.05).After 4 weeks of treatment,MOAS score,PANSS score of the observation group were lower than those of the control group(P<0.05).MoCA score and MMSE score were higher than those of the control group(P<0.05).The incidence rates of adverse reactions in the two groups were comparable(P>0.05).Conclusion Ziprasidone combined with MECT is effective in the treatment of schizophrenia,which helps to improve the patients’symptoms,aggressive behavior and cognitive function,with high safety.

关 键 词：精神分裂症 齐拉西酮 改良电休克 攻击行为 阳性与阴性症状量表 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]