度洛西汀联合米氮平对合并躯体疼痛的抑郁症患者的效果  

The Effect of duloxetine combined with lmirtazapine in depression patients with somatic pain

作　　者：周莉霞 王学刚 ZHOU Lixia;WANG Xuegang(Pharmacy Department of Liaocheng Fourth People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市第四人民医院药学部,聊城252000

出　　处：《国际精神病学杂志》2024年第4期1137-1139,共3页Journal Of International Psychiatry

摘　　要：目的探讨度洛西汀联合小剂量米氮平治疗抑郁症合并躯体疼痛的临床疗效。方法将聊城市第四人民医院2021年1月~2022年12月84例抑郁症合并躯体疼痛按抽签法分为两组,对照组,观察组各42例。对照组采用度洛西汀治疗,观察组采用度洛西汀联合小剂量米氮平治疗。比较两组患者治疗前与治疗8周后焦虑与抑郁自评量表[Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS)],简化McGill疼痛问卷评分差异。结果两组治疗后SAS评分,SDS评分较治疗前均显著降低(P<0.05),但治疗后观察组SAS评分,SDS评分显著低于对照组(P<0.05);两组治疗后McGill问卷疼痛分级指数(pain rating index,PRI),视觉模拟量表(visualanalogue scale,VAS),疼痛现有强度(present pain intensity,PPI)较治疗前均显著降低(P<0.05),且治疗后观察组三项评分均显著低于对照组(P<0.05)。结论度洛西汀联合小剂量米氮平治疗抑郁症合并躯体疼痛在改善焦虑,抑郁情绪,减轻躯体疼痛方面效果更佳。Objective To investigate the clinical efficacy of duloxetine combined with low dose mirtazapine in the treatment of depression complicated with somatic pain.Methods Eighty-four cases of depression combined with somatic pain in Liaocheng Fourth People's Hospital from January 2021 to December 2022 were divided into two groups according to the lottery method of randomization,42 cases in the control group and 42 cases in the observation group.The control group was treated with duloxetine,and the observation group was treated with duloxetine combined with low-dose mirtazapine.Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and simplified McGill pain questionnaire were compared between the two groups of patients before treatment and after 8 weeks of treatment.Results SAS scores and SDS scores were significantly lower in both groups after treatment than before treatment(P<0.05).However,SAS score and SDS score of observation group were significantly lower than those of control group after treatment(P<0.05).The McGill questionnaire pain rating index(PRI),visualanalogue scale(VAS),and pain intensity(PPI)were significantly lower in both groups after treatment than before(P<0.05).And all three scores in the observation group were significantly lower than those in the control group after treatment(P<0.05).Conclusion Duloxetine combined with low dose mirtazapine is more effective in improving anxiety,depression and relieving physical pain in the treatment of depression combined with somatic pain.

关 键 词：度洛西汀 小剂量米氮平 抑郁症 躯体疼痛 

分 类 号：R749.053[医药卫生—神经病学与精神病学]