团体认知行为疗法联合药物对双相情感障碍躁狂发作患者的效果  

Effects of group cognitive behavioral therapy combined with drug on manic episodes,oxidative stress markers and sleep quality in patients with bipolar disorder

作　　者：王钦文 陈长浩 王兰兰 李迎晨 沈子童[1] WANG Qinwen;CHEN Changhao;WANG Lanlan(Anhui Suzhou Second People's Hospital,Suzhou 234000,China)

机构地区：[1]宿州市第二人民医院,宿州234000

出　　处：《国际精神病学杂志》2024年第4期1151-1153,1160,共4页Journal Of International Psychiatry

摘　　要：目的探讨团体认知行为疗法(Group cognitive behavioral therapy,G-CBT)联合药物对双相情感障碍(Bipolar disorder,BD)患者躁狂发作症状,氧化应激指标及睡眠质量的影响。方法选取我院2020年9月~2022年10月期间108例BD躁狂发作患者为研究对象,各54例,依照治疗方式分为药物组和认知组。药物组予药物治疗,认知组在药物组基础上增加G-CBT,比较两组躁狂与精神症状,睡眠质量,氧化应激指标。结果认知组治疗8周后Bech-Rafaelsen躁狂评估量表,阳性和阴性综合征量表评分低于药物组(P<0.05)。认知组治疗8周后入睡时间,睡眠质量,睡眠时间评分低于药物组(P<0.05)。认知组治疗8周后丙二醛水平低于药物组;超氧化物歧化酶,谷胱甘肽过氧化物酶水平高于药物组(P<0.05)。结论G-CBT联合药物控制可调节BD患者氧化应激指标,改善躁狂发作,提高睡眠质量。Objective To investigate the effects of Group cognitive behavioral therapy(G-CBT)combined with medication on manic episodes,oxidative stress markers and sleep quality in patients with Bipolar disorder(BD).Methods 108 cases of BD patients in our hospital from September 2020 to October 2022 were selected as the study objects,with 54 cases in each case.They were divided into drug group and cognitive group according to treatment methods.The drug group was treated with medication,and the cognitive group was treated with G-CBT.Manic and psychiatric symptoms,sleep quality,and oxidative stress indexes were compared between the two groups.Results After 8 weeks of treatment,Bech-Rafaelsen mania Assessment Scale,positive and negative syndrome scale scores in cognitive group were lower than those in drug group(P<0.05).After 8 weeks of treatment,the scores of sleep time,sleep quality and sleep time in cognitive group were lower than those in drug group(P<0.05).The level of malondialdehyde in cognitive group was lower than that in drug group after 8 weeks of treatment;The levels of superoxide dismutase and glutathione peroxidase were higher than those in drug group(P<0.05).Conclusion Group cognitive behavioral therapy combined with drug control can regulate oxidative stress markers,improve manic episodes,and improve sleep quality in patients with bipolar disorder.

关 键 词：团体认知行为疗法 双相情感障碍 氧化应激 睡眠质量 

分 类 号：R749.055[医药卫生—神经病学与精神病学]