西酞普兰合并米氮平对帕金森病伴抑郁患者的效果  

Effect of citalopram combined with mirtazapine on Parkinson’s disease patients with depression

作　　者：俞广权 吴仕鹏 徐文斌 杨惠荣 YU Guangquan;WU Shipeng;XU Wenbin(Shaowu Municipal Hospital,neurology department,Shaowu 354000,China)

机构地区：[1]邵武市立医院神经内科,邵武354000

出　　处：《国际精神病学杂志》2024年第4期1203-1205,1213,共4页Journal Of International Psychiatry

摘　　要：目的探讨帕金森病(Parkinson's disease,PD)伴抑郁患者合用米氮平治疗的临床效果。方法于2019年9月~2022年9月采集病例资料入档,对象为医院收治的PD伴抑郁患者,共计纳入80例,纳入对象基于“随机数字表法”1∶1分组,划分为对照组(予以西酞普兰治疗)与观察组(予以西酞普兰+米氮平治疗),各组均40例;观察对比两组焦虑抑郁程度,睡眠质量,帕金森病统一评分量表(Unified Parkinson's Disease Rating Scale,UPDRS-Ⅲ),日常生活能力,不良反应发生率。结果治疗后,两组汉密顿焦虑量表(Hamilton anxiety scale,HAMA),汉密顿抑郁量表(Hamilton depression scale,HAMD)评分均降低,且观察组评分更低(P<0.05);治疗后,两组匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分均明显降低,且观察组较对照组PSQI评分显著低(P<0.05);治疗后,两组UPDRS-Ⅲ评分均下降,日常生活活动能力量表(Activities of daily living,ADL)评分均升高,且观察组较对照组更优(P<0.05);两组不良反应发生率比较无明显差异(P>0.05)。结论PD伴抑郁患者应用西酞普兰联合米氮平治疗,可发挥良好抗抑郁作用,提高患者睡眠质量,改善其心理状态,且用药安全性好。Objective To explore the clinical efficacy of using mirtazapine in the treatment of Parkinson's disease(PD)patients with depression.Methods Case data were collected and filed from September 2019 to September 2022.The subjects were PD patients with depression admitted to the hospital,with a total of 80 cases included.The subjects were divided into a control group(treated with citalopram)and an observation group(treated with citalopram+mirtazapine)based on a 1∶1 random number table method,with 40 cases in each group;Observe and compare the levels of anxiety and depression,sleep quality,Unified Parkinson's Disease Rating Scale(UPDRSⅢ),daily living ability,and incidence of adverse reactions between two groups.Results After treatment,the Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)scores of both groups decreased,and the observation group had lower scores(P<0.05).After treatment,the Pittsburgh Sleep Quality Index(PSQI)scores of both groups were significantly reduced,and the observation group had significantly lower PSQI scores than the control group(P<0.05).After treatment,the UPDRSⅢscores of both groups decreased,and the Activities of Daily Living(ADL)scores increased.The observation group performed better than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of citalopram combined with mirtazapine in the treatment of PD patients with depression can exert good antidepressant effects,improve sleep quality,improve their psychological state,and have good medication safety.

关 键 词：米氮平 帕金森病 抑郁 焦虑 

分 类 号：R749.05[医药卫生—神经病学与精神病学]