艾司氯胺酮对剖宫产术后应激及产后抑郁发生率的影响  

The effect of esketamine on the incidence of stress and postpartum depression after Caesarean section

作　　者：高顺恒 刁怀悦 陈福腾 栾恒飞[1] GAO Shunheng;DIAO Huaiyue;CHEN Futeng(Department of Anesthesiology,Lianyungang First People's Hospital,Lianyungang 222000,China)

机构地区：[1]连云港市第一人民医院麻醉科,编号:222000

出　　处：《国际精神病学杂志》2024年第4期1210-1213,共4页Journal Of International Psychiatry

基　　金：博士科研基金课题(编号:BS202005)。

摘　　要：目的分析艾司氯胺酮对产妇剖宫产术后应激与产后抑郁发生情况的影响。方法将2021年3月~2023年3月间在本院行剖宫产手术的108例产妇纳为研究对象,将产妇按照随机数字表法分为对照组,观察组,每组54例。对照组产妇术后采用布托啡诺进行自控静脉镇痛治疗,观察组产妇术后加用艾司氯胺酮进行自控静脉镇痛治疗。观察产妇术后相关应激反应评价变化与产后抑郁的发生情况。结果观察组产妇产后不同时间点的视觉模拟评分法(visualanaloguescale,VAS)评分均低于对照组,且患者产后1周的产后抑郁发生率更低(P<0.05)。两组产妇产后不同时间的简易智力状态检查量表(mini-mental state examination,MMSE)评分与不良反应发生情况均无明显差异(P>0.05)。结论艾司氯胺酮对于减轻剖宫产产妇产后疼痛具有良好表现,有助于缓解产妇的术后应激反应,降低产后抑郁的发生风险。Objective To analyze the effect of esketamine on stress and postpartum depression after Caesarean section.Methods 108 pregnant women who underwent Caesarean section in our hospital from March 2021 to March 2023 were enrolled as the study subjects.The pregnant women were divided into control group and observation group according to random number table,with 54 cases in each group.The patients in the control group were treated with butorphanol for PCIA after operation,and the patients in the observation group were treated with esketamine for PCIA after operation.The changes in postpartum stress response evaluation and the occurrence of postpartum depression in postpartum women after surgery were compared between two groups.Results The visual analog scale(VAS)scores of postpartum women in the observation group were lower than those in the control group at different time points,and the incidence of postpartum depression was lower in patients after one week postpartum(P<0.05).There was no significant difference in the scores of the mini mental state examination(MMSE)and the incidence of adverse reactions between the two groups of postpartum women at different times(P>0.05).Conclusion Esketamine has a good performance in relieving postpartum pain of parturients after Caesarean section,which is helpful to alleviate the stress reaction of parturients after operation and reduce the risk of postpartum depression.

关 键 词：艾司氯胺酮 剖宫产 产后抑郁 

分 类 号：R749[医药卫生—神经病学与精神病学]