参菝抗瘤液对结直肠腺瘤性息肉术后肠道功能、炎症指标及复发情况的影响  

Effect of Shenba Kangliu Liquid on intestinal function,inflammatory index and recurrence after colorectal adenomatous polyp surgery

作　　者：杭丽[1] 张耀辉[1] 孙文恺 Hang Li;Zhang Yaohui;Sun Wenkai(Department of Spleen and Stomach Diseases,Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Zhangjiagang 215600,China)

机构地区：[1]南京中医药大学附属张家港市中医医院脾胃病科,江苏省215600

出　　处：《中华消化病与影像杂志（电子版）》2024年第5期413-416,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的分析参菝抗瘤液对结直肠腺瘤性息肉术后肠道功能、炎症指标及复发情况的影响。方法选取2021年1月至2022年9月张家港市中医医院收治的400例结直肠腺瘤性息肉患者,随机分为观察组(n=200)、对照组(n=200),2组均接受肠镜下息肉切除术治疗,观察组接受参菝抗瘤液治疗,持续2周。对比2组患者术后肠道功能恢复时间、肠壁恢复情况、血清炎症指标及复发率。结果2组患者术后肠鸣音恢复时间、首次进食时间、首次排便时间比较,差异无统计学意义(P>0.05)。2组患者术后14 d肠壁厚度、缺损长度、中性粒细胞计数(NEU)、中性粒细胞与淋巴细胞比值(NLR)、系统性免疫炎症指数(SII)均较术后1 d下降,淋巴细胞计数(LYM)均较术前1 d升高;观察组术后14 d肠壁厚度、缺损长度、NEU、NLR、SII均低于对照组,LYM高于对照组(P<0.05)。观察组术后6个月、1年复发率及总复发率均低于对照组(P<0.05)。结论参菝抗瘤液能够在不影响结直肠腺瘤性息肉患者术后肠道功能恢复的基础上,促进患者肠壁恢复、炎症指标改善,对降低术后短期复发率也有积极作用。Objective To analyze the effect of Shenba Kangliu Liquid on postoperative intestinal function,inflammatory indexes,and recurrence of colorectal adenomatous polyps.Methods A total of 400 patients with colorectal adenomatous polyps admitted to Zhangjiagang Hospital of Traditional Chinese Medicine from January 2021 to September 2022 were selected and randomly divided into an observation group(n=200)and a control group(n=200).Both groups underwent polypectomy under colonoscopy,while the observation group received Shenba Kangliu Liquid treatment for 2 weeks.The recovery time of intestinal function,the restoration of intestinal wall,serum inflammatory indexes and recurrence rate between the two groups were compared.Results There were no statistically significant differences in the recovery time of bowel sounds,time to initiate eating,and time to first defecation between the two groups(P>0.05).The thickness of the intestinal wall,the length of the defect,neutrophil count(NEU),neutrophil to lymphocyte ratio(NLR)and systemic immune inflammatory index(SII)decreased in both groups on the 14th day after the operation compared to the 1st day after the operation,while lymphocyte count(LYM)increased.Furthermore,on the 14th day after the operation,the thickness of the intestinal wall,the length of the defect,NEU,NLR,and SII in the observation group were lower than those in the control group(P<0.05),while LYM was higher than that in the control group(P<0.05).The 6-month and 1-year recurrence rates and the total recurrence rate of the observation group were lower than those of the control group(P<0.05).Conclusion Shenba Kangliu Liquid can promote the recovery of the intestinal wall and the improvement of inflammatory indexes in patients with colorectal adenomatous polyps without affecting the recovery of intestinal function after the operation.It also has a positive effect on reducing the recurrence rate at 6 months and 1 year after the operation.

关 键 词：结直肠腺瘤性息肉 参菝抗瘤液 肠道功能 炎症指标 复发 

分 类 号：R735.34[医药卫生—肿瘤]