慢性萎缩性胃炎患者幽门螺杆菌感染与炎性细胞因子及病理特征的关系  

Relationship between Helicobacter pylori infection and inflammatory cytokines and pathological features in patients with chronic atrophic gastritis

作　　者：杨卫东[1] 周威[1] 向洪涛[1] Yang Weidong;Zhou Wei;Xiang Hongtao(Department of Gastroenterology,Daqing Fourth Hospital,Daqing 163000,China)

机构地区：[1]大庆市第四医院消化内科,黑龙江163000

出　　处：《中华消化病与影像杂志（电子版）》2024年第5期459-464,共6页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨慢性萎缩性胃炎(CAG)患者中幽门螺杆菌(Hp)感染与炎性细胞因子及病理特征关系。方法选取2020年1月至2021年1月大庆市第四医院收治CAG患者152例,胃镜检查收集胃黏膜病变组织标本,统计Hp感染情况,分析Hp感染与炎症细胞因子和病理特征相关性。结果152例CAG患者中Hp感染阳性84例,阴性68例。两组间质炎细胞中IL-1以弱阳性表达为主,Hp阳性组间质炎细胞中IL-1阳性和强阳性表达率明显高于阴性组(P<0.05)。两组间质炎细胞中TNF-α均以强阳性为主、TNF-β以阳性为主,差异无统计学意义(P>0.05)。两组胃小凹上皮中IL-1以弱阳性为主、TNF-α以强阳性为主,差异无统计学意义(P>0.05);阴性组TNF-β以强阳性为主,阳性组则以阳性为主,但差异无统计学意义(P>0.05)。阴性组中慢性炎症程度以中度为主,其次为轻度,阳性组以中度为主,其次为重度,两组差异有统计学意义(P<0.01);两组萎缩程度、肠化生程度差异无统计学意义(P>0.05)。相关性分析显示,慢性炎症程度与CAG患者胃小凹上皮和间质炎细胞IL-1水平呈正相关(P<0.05),与TNF-α、TNF-β水平无相关性(P>0.05);萎缩、肠化生与胃小凹上皮和间质炎细胞IL-1、TNF-α、TNF-β水平无相关性(P>0.05)。结论IL-1在胃小凹上皮和间质炎细胞表达与Hp感染和CAG症程度相关,与萎缩和肠化生关系需进一步研究。Objective To explore the relationship between Helicobacter pylori(Hp)infection and inflammatory cytokines and pathological characteristics in patients with chronic atrophic gastritis(CAG).Methods A total of 152 patients with CAG admitted to Daqing Fourth Hospital from January 2020 to January 2021 were selected for gastroscopy examination,and tissue samples of gastric mucosal lesions were collected.The infection status of Hp was analyzed,and the correlation between Hp infection and inflammatory cytokines and pathological characteristics was analyzed.Results There were 84 positive cases of Hp infection and 68 negative cases in 152 patients with CAG.The negative and positive groups of Hp showed weak positive expression of IL-1,and the positive and strong positive expression rates of IL-1 in the positive group were significantly higher than those in the negative group(P<0.05).TNF-α was mainly strongly positive in both groups of interstitial inflammatory cells,while TNF-β was mainly positive,with no statistically significant difference(P>0.05).There was no statistically significant difference between the two groups of gastric pit epithelium(P>0.05),with weak positive IL-1 and strong positive TNF-α.The negative group showed strong positivity for TNF-β,while the positive group showed positivity,but there was no statistically significant difference(P>0.05).The negative group was mainly characterized by moderate inflammation,followed by mild inflammation,while the positive group was mainly characterized by moderate inflammation,followed by severe inflammation,with a statistically significant difference(P<0.01).There was no statistically significant difference in the degree of atrophy and intestinal metaplasia between the negative and positive groups of Hp(P>0.05).Correlation analysis showed that the degree of chronic inflammation was positively correlated with the IL-1 levels of gastric pit epithelium and stromal inflammatory cells in patients with CAG(P<0.05),but not with the levels of TNF-α and TNF-β(P>0.05).There

关 键 词：慢性萎缩性胃炎 幽门螺杆菌 白细胞介素1 肿瘤坏死因子Α 肿瘤坏死因子Β 

分 类 号：R573.3[医药卫生—消化系统]