氨基酸手性分子传感识别研究进展  

Research Progress in Chiral Molecular Sensing Recognition of Amino Acids

作　　者：杜莹莹 亓丽梅 赵桂英 刘浩驰 DU Yingying;QI Limei;ZHAO Guiying;LIU Haochi(School of Electronic Engineering,Beijing University of Posts and Telecommunications,Beijing 100876,China)

机构地区：[1]北京邮电大学电子工程学院,北京100876

出　　处：《聊城大学学报（自然科学版）》2024年第5期144-154,共11页Journal of Liaocheng University:Natural Science Edition

基　　金：国家自然科学基金项目(62175016,61875017)资助。

摘　　要：氨基酸是生物系统中最重要的一类分子,在疾病诊断、药物合成、生命体特征监测等方面具有不可替代的作用。氨基酸手性分子对映体往往有类似的物理性质,但却具有完全不同的药理作用,因此高灵敏度氨基酸对映体的手性识别受到学术界的广泛关注。本论文对氨基酸手性识别领域进行了调研,归纳了近五年氨基酸手性分子的传感识别方法,重点总结了光谱学传感方法、石英晶体天平传感方法和电化学传感方法的现有成果及发展趋势,并对氨基酸手性识别的未来研究方向进行了展望,该工作将为手性分子的识别和发展提供重要参考和指导。Amino acids are the most important molecules in biological systems,and they play an irreplaceable role in disease diagnosis,drug synthesis,and vital characteristics monitoring.Amino acid chiral molecular enantiomers often have similar physical properties but have completely different pharmacological effects,so the chiral recognition of high-sensitivity amino acid enantiomers has attracted extensive attention from the academic community.In this paper,we investigated the field of amino acid chiral recognition,summarized the sensing and identification methods of amino acid chiral molecules in the past five years,focused on the existing achievements and development trends of spectroscopic sensing methods,quartz crystal balance sensing methods and electrochemical sensing methods,and prospected the future research direction of amino acid chiral recognition,which will provide important reference and guidance for the identification and development of chiral molecules.

关 键 词：氨基酸 手性识别 光谱 传感方法 

分 类 号：Q503[生物学—生物化学] TP212[自动化与计算机技术—检测技术与自动化装置]