慢性牙周炎患者血清CCL21、IRF4水平及临床意义  

Serum CCL21 and IRF4 levels and their clinical significance in patients with chronic periodontitis

作　　者：田碧媛 李俊梅 曹建强 TIAN Biyuan;LI Junmei;CAO Jianqiang(Department of Stomatology,Handan People′s Hospital,Handan,Hebei 056001,China)

机构地区：[1]河北省邯郸市人民医院口腔科,河北邯郸056001

出　　处：《检验医学与临床》2024年第18期2690-2693,2697,共5页Laboratory Medicine and Clinic

基　　金：2022年度河北省医学科学研究课题计划(20220493)。

摘　　要：目的探讨慢性牙周炎患者血清CC基序趋化因子配体(CCL)21、干扰素调节因子(IRF)4水平及临床意义。方法选取2020年12月至2023年6月河北省邯郸市人民医院收治的124例慢性牙周炎患者作为患病组,另选取同期在河北省邯郸市人民医院体检的82例健康志愿者作为对照组,并根据慢性牙周炎严重程度将慢性牙周炎患者分为轻症组和中重症组。采用酶联免疫吸附试验检测所有研究对象血清CCL21、IRF4水平,评估慢性牙周炎患者的牙周临床指标[牙周袋探诊深度(PD)、附着丧失(AL)、牙龈沟出血指数(SBI)、牙龈指数(GI)、牙菌斑指数(PLI)]。采用Pearson相关分析慢性牙周炎患者血清CCL21、IRF4水平与牙周临床指标的相关性。绘制受试者工作特征(ROC)曲线分析血清CCL21、IRF4对慢性牙周炎患者病情严重程度的预测价值。结果患病组血清CCL21、IRF4水平高于对照组,差异均有统计学意义(P<0.05)。轻症组有66例患者,中重症组有58例患者。中重症组患者血清CCL21、IRF4水平及PD、SBI、AL、GI、PLI高于轻症组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,慢性牙周炎患者血清CCL21、IRF4水平与PD、SBI、AL、GI、PLI呈正相关(P<0.05)。ROC曲线分析结果显示,2项指标联合预测中重症慢性牙周炎的曲线下面积(AUC)为0.914,大于CCL21、IRF4单独预测的AUC(Z_(联合=CCL21)=2.977,P=0.003;Z_(联合=IRF4)=2.412,P=0.016)。结论慢性牙周炎患者的血清CCL21、IRF4水平升高,且CCL21、IRF4对慢性牙周炎患者病情严重程度具有一定预测价值。Objective To investigate the levels and clinical significance of serum CC motif chemokine ligand(CCL)21 and interferon regulatory factor(IRF)4 in patients with chronic periodontitis.Methods A total of 124 patients with chronic periodontitis admitted to Handan People′s Hospital from December 2020 to June 2023 were selected as the disease group,and 82 healthy volunteers who underwent physical examination in Handan People′s Hospital during the same period were selected as the control group.The patients with chronic periodontitis were divided into mild group and moderate-severe group according to the severity of chronic periodontitis.The serum levels of CCL21 and IRF4 in all subjects were detected by enzyme-linked immunosorbent assay.The periodontal clinical indicators[periodontal pocket probing depth(PD),attachment loss(AL),sulcus bleeding index(SBI),gingival index(GI),and dental plaque index(PLI)]of patients with chronic periodontitis were evaluated.Pearson correlation analysis was used to analyze the correlation between serum CCL21 and IRF4 levels and periodontal clinical indicators in patients with chronic periodontitis.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum CCL21 and IRF4 for the severity of chronic periodontitis.Results The serum levels of CCL21 and IRF4 in the disease group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).There were 66 patients in the mild group and 58 patients in the moderate-severe group.The serum levels of CCL21 and IRF4,PD,SBI,AL,GI and PLI in the moderate-severe group were higher than those in the mild group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum CCL21 and IRF4 levels in patients with chronic periodontitis were positively correlated with PD,SBI,AL,GI,and PLI(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combined prediction of CCL21 and IRF4 was 0.914,which was grea

关 键 词：慢性牙周炎 趋化因子21 干扰素调节因子4 病情评估 相关性 

分 类 号：R781.4[医药卫生—口腔医学] R446.1[医药卫生—临床医学]