神经生长因子局部注射联合根管充填治疗老年慢性牙髓炎患者的效果  

Effects of local injection of nerve growth factor combined with root canal filling in treatment of elderly patients with chronic pulpitis

作　　者：王少一 WANG Shaoyi(Department of Stomatology of Zhangzhongjing Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳张仲景医院口腔科,河南南阳473000

出　　处：《中国民康医学》2024年第18期61-63,70,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察神经生长因子(NGF)局部注射联合根管充填治疗老年慢性牙髓炎患者的效果。方法:选取2020年7月至2023年6月该院收治的98例老年慢性牙髓炎患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各49例。对照组采用根管充填治疗,研究组在对照组基础上联合NGF局部注射治疗,比较两组临床疗效,治疗前后牙周指标[牙龈指数(GI)、牙周探诊深度(PD)、菌斑指数(PLI)]水平、炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)]水平、口腔健康生命质量[口腔健康影响程度量表(OHIP-14)]评分,以及不良反应发生率。结果:研究组治疗总有效率为87.76%(43/49),高于对照组的69.39%(34/49),差异有统计学意义(P<0.05);治疗后,研究组PD、CRP、PCT、WBC水平和GI、PLI、OHIP-14评分均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:NGF局部注射联合根管充填治疗老年慢性牙髓炎患者可提高治疗总有效率,降低牙周指标、炎性指标水平和口腔健康生命质量评分,效果优于单纯根管充填治疗。Objective:To observe effects of local injection of nerve growth factor(NGF)combined with root canal filling in treatment of elderly patients with chronic pulpitis.Methods:A prospective study was conducted on 98 elderly patients with chronic pulpitis admitted to this hospital from July 2020 to June 2023.According to the random number table method,they were divided into study group and control group,49 cases in each group.The control group was treated with root canal filling,while the study group was treated with NGF local injection on the basis of that of the control group.The clinical efficacy,the periodontal indexes[gingival index(GI),periodontal probing depth(PD),plaque index(PLI)]levels,the inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)]levels,the oral health quality of life[oral health impact profile(OHIP-14)]score,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 87.76%(43/49),which was higher than 69.39%(34/49)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PD,CRP,PCT,and WBC,and scores of GI,PLI and OHIP-14 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:NGF local injection combined with root canal filling in the treatment of the elderly patients with chronic pulpitis can improve the total effective rate of treatment and reduce the periodontal index and inflammatory index levels and the oral health quality of life scores.Moreover,it is superior to simple root canal filling treatment.

关 键 词：神经生长因子 根管充填 老年 慢性牙髓炎 口腔健康 不良反应 

分 类 号：R781.31[医药卫生—口腔医学]