Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications  

作　　者：Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu 

机构地区：[1]Tissue Engineering and Stem Cell Group,Singapore Eye Research Institute,Singapore [2]Yong Loo Lin School of Medicine,National University of Singapore,Singapore [3]Department of Cornea and External Eye Disease,Singapore National Eye Center,Singapore [4]Ophthalmology and Visual Sciences Academic Clinical Program,Duke-NUS Medical School,Singapore

出　　处：《Neural Regeneration Research》2025年第8期2169-2180,共12页中国神经再生研究（英文版）

摘　　要：Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus.Diabetic corneal neuropathy refers to the progressive damage of corneal nerves.Diabetic retinopathy has traditionally been considered as damage to the retinal microvasculature.However,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural tissues.Diabetic retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular screening.However,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface impairment.Several studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic hyperglycemia.This review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal neuropathy.We also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关 键 词：CORNEA corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]