Neurocircuit regeneration by extracellular matrix reprogramming  

作　　者：Shengzhang Su Ian N.Levasseur Kimberly M.Alonge 

机构地区：[1]Department of Medicinal Chemistry,University of Washington,Seattle,WA,USA [2]Department of Chemistry,University of Washington,Seattle,WA,USA [3]Department of Medicine,University of Washington Medicine Diabetes Institute,Seattle,WA,USA

出　　处：《Neural Regeneration Research》2025年第8期2300-2301,共2页中国神经再生研究（英文版）

基　　金：supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA);National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA);Department of Defense(DoD)grant AZ210089(to KMA)。

摘　　要：The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关 键 词：MATRIX PROGRAMMING 

分 类 号：Q42[生物学—神经生物学]