榄香烯注射液对肝癌患者增效减毒作用的系统评价  

The synergistic and reducing toxicity effect of elemene injectionfor liver cancer:A Systermreview

作　　者：赵粉莹 陈莉华 刘金响 宋睿 司海龙 ZHAO Fen-ying;CHENG Li-hua;LIU Jing-xiang(Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi,712046,China;不详)

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712046 [2]陕西中医药大学第二附属医院

出　　处：《中西医结合肝病杂志》2024年第9期812-817,共6页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家自然科学基金项目(No.81704066);陕西省科技厅课题(No.2022JM-448)。

摘　　要：目的:通过Meta分析系统评价榄香烯注射液对肝癌患者增效减毒作用,为肝癌的治疗提供可靠的循证学依据。方法:检索中国期刊全文数据库(CNKI)、万方数据库、维普数据库及PubMed等数据库,检索时间为建库至2024年2月,全面检索关于榄香烯注射液对肝癌患者的临床随机对照试验(RCT)的文献,运用RevMan 5.3软件进行数据统计分析。结果:最终纳入13篇研究文献。分析结果:临床缓解率[OR=3.60,95%CI(2.37,5.45),P<0.01];肝功能相关指标:ALT[MD=-21.32,95%CI(-32.34,-10.40),P<0.01];AST[MD=-18.97,95%CI(-32.09,-5.85),P<0.01];TBil[MD=-4.06,95%CI(-7.57,-0.54),P=0.02];AFP[MD=-45.68,95%CI(-80.13,-11.23),P=0.09];CD4^(+)[MD=4.90,95%CI(3.11,6.69),P<0.01];CD8^(+)[MD=-3.62,95%CI(-7.30,0.06),P=0.05];CD4^(+)/CD8^(+)[MD=0.31,95%CI(0.26,0.36),P<0.01];骨髓抑制[OR=0.40,95%CI(0.23,0.72),P=0.002];恶心呕吐[OR=0.38,95%CI(0.23,0.64),P<0.01]。结论:榄香烯可以有效缓解肝癌患者的骨髓抑制、胃肠道损伤,调节免疫应答,提高药物敏感性的同时可降低药物的毒副反应,并具有一定的肝功能保护作用。Objective:To systematically evaluate the synergistic and attenuated effects of elemene injection on patients with liver cancer by Meta-analysis,and to provide reliable evidence-based basis for the treatment of liver cancer patients.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP database,and PubMed were searched for randomized controlled trials(RCTS)on elemene injection in patients with liver cancer up to February 2024.RevMan 5.3 software was used to analyze the data.Results:A total of 13 studies were included.The results of the analysis:clinical remission rate[OR=3.60,95%CI(2.37,5.45),P<0.01].Liver function-related indicators:ALT[MD=-21.32,95%CI(-32.34,-10.40),P<0.01];AST[MD=-18.97,95%CI(-32.09,-5.85),P<0.01];TBil[MD=-4.06,95%CI(-7.57,-0.54),P=0.02];AFP[MD=-45.68,95%CI(-80.13,-11.23),P=0.009];CD4^(+)[MD=4.90,95%CI(3.11,6.69),P<0.01];CD8^(+)[MD=-3.62,95%CI(-7.30,0.06),P=0.05];CD4^(+)/CD8^(+)[MD=0.31,95%CI(0.26,0.36),P<0.01];Bone marrow suppression[OR=0.40,95%CI(0.23,0.72),P=0.002];Nausea and vomiting[OR=0.38,95%CI(0.23,0.64),P<0.01].Conclusion:Elemene can effectively alleviate bone marrow suppression,gastrointestinal injury,regulate immune response,improve drug sensitivity,reduce drug side effects,and protect liver function in patients with liver cancer.

关 键 词：肝癌 榄香烯 不良反应 META分析 

分 类 号：R735.7[医药卫生—肿瘤]