南疆地区女性BMI与乳腺癌临床特征、分子分型的相关性研究  

Study on the correlation between BMI and clinical characteristics and molecular typing of breast cancer in women in southern Xinjiang

作　　者：耿永勇 尹颜新 赖国威 赵丹 郑锐年[3] 李坊铭[4] 尚玉芝 杨晓燕 GENG Yongyong;YIN Yanxin;LAI Guowei;ZHAO Dan;ZHENG Ruinian;LI Fangming;SHANG Yuzhi;YANG Xiaoyan(Oncology Department,General Hospital of the Third Division of Xinjiang Production and Construction Corps,Tumushuke 843900;General Surgery Department,the Tenth Affiliated Hospital of Southern Medical University/Dongguan People's Hospital,Dongguan 523059;Oncology Department,the Tenth Affiliated Hospital of Southern Medical University/Dongguan People's Hospital/Dongguan Institute of Cancer Clinical Medicine/Dongguan Key Laboratory of Tumor Precision Diagnosis and Treatment,Dongguan 523059;Oncology Department,Jiangmen Central Hospital,Jiangmen 529000,China)

机构地区：[1]新疆生产建设兵团第三师总医院肿瘤科,新疆图木舒克843900 [2]南方医科大学第十附属医院/东莞市人民医院普外科,广东东莞523059 [3]南方医科大学第十附属医院/东莞市人民医院肿瘤科/东莞市肿瘤临床医学研究所/东莞市肿瘤精准诊疗重点实验室,广东东莞523059 [4]江门市中心医院肿瘤科,广东江门529000

出　　处：《临床医学研究与实践》2024年第26期38-41,共4页Clinical Research and Practice

基　　金：2022年东莞市社会发展科技项目(No.20221800901582)。

摘　　要：目的探讨南疆地区女性体质指数(BMI)与乳腺癌临床特征、分子分型的相关性。方法回顾性选取2020年1月至2022年12月在新疆生产建设兵团第三师总医院进行治疗的165例女性乳腺癌患者为研究对象,依据住院时的BMI将其分为消瘦组(BMI<18.5 kg/m2)、正常组(BMI 18.5~23.9 kg/m2)、超重组(BMI24.0~27.9 kg/m2)以及肥胖组(BMI≥28.0 kg/m2)。比较四组患者的一般资料、病理特征以及主要分子分型。结果四组患者的高血脂、绝经状态比较,差异具有统计学意义(P<0.05)。四组患者的淋巴结转移情况比较,差异具有统计学意义(P<0.05)。四组患者的人表皮生长因子受体-2(HER-2)阳性占比比较,差异具有统计学意义(P<0.05)。结论南疆地区女性BMI与乳腺癌患者的高血脂、绝经状态、淋巴结转移以及HER-2阳性有关。Objective To explore the correlation between body mass index(BMI)and clinical characteristics and molecular typing of breast cancer in women in southern Xinjiang.Methods A total of 165 female breast cancer patients who were treated in the General Hospital of the Third Division of Xinjiang Production and Construction Corps from January 2020 to December 2022 were retrospectively selected as the research objects.According to the BMI at the time of hospitalization,the patients were divided into lean group(BMI<18.5 kg/m2),normal group(BMI 18.5-23.9 kg/m2),overweight group(BMI 24.0-27.9 kg/m2),and obese group(BMI≥28 kg/m2).The general data,pathological features and main molecular typing of the four groups were compared.Results There were statistically significant differences in hyperlipidemia and menopausal status among the four groups(P<0.05).There was statistically significant difference in lymph node metastasis among the four groups(P<0.05).There was statistically significant difference in the proportion of positive human epidermal growth factor receptor-2(HER-2)among the four groups(P<0.05).Conclusion BMI of women in southern Xinjiang is associated with hyperlipidemia,menopausal status,lymphatic metastasis and HER-2 positive in breast cancer patients.

关 键 词：南疆地区 乳腺癌 体质指数 淋巴结转移 分子分型 

分 类 号：R737.9[医药卫生—肿瘤]