Alport综合征肾移植后新发非典型抗肾小球基膜肾炎  

Atypical anti-glomerular basement membrane disease after renal transplantation of Alport syndrome patient

作　　者：姚昕辰 徐峰 曾彩虹 YAO Xinchen;XU Feng;ZENG Caihong(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210016,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院),国家肾脏疾病临床医学研究中心,南京210016

出　　处：《肾脏病与透析肾移植杂志》2024年第4期382-387,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金项目(82070793);江苏省卫生健康委员会医学科研项目(ZD2021018)。

摘　　要：青年男性患者,自体肾活检诊断为Alport综合征,肾移植术后6年,病程中血清肌酐和蛋白尿反复增高,肾活检组织学为肾小球系膜增生性病变,IgG沿肾小球基膜(GBM)呈线性沉积,电镜下观察肾小球系膜区有电子致密物沉积。结合临床,考虑为移植肾非典型抗GBM肾炎,同时伴混合性排斥反应、免疫复合物相关肾小球病。A 19-year-old male presented with repeated increases of blood creatinine and urine protein six years after renal transplantation due to Alport syndrome and CKD stage 5D.Renal biopsy revealed mesangial proliferative glomerulonephritis,and linear deposition of IgG along glomerular basement membrane(GBM),and electron dense deposits in mesangial region on electron microscopy.The final diagnosis was allograft post-transplant anti-GBM nephritis,along with mixed rejection and immune complex nephritis.

关 键 词：肾移植 ALPORT综合征 移植后非典型抗肾小球基膜肾炎 免疫复合物相关肾小球病 

分 类 号：R699.2[医药卫生—泌尿科学]