加巴喷丁联合卡马西平治疗难治性癫痫的效果  

Effect of Gabapentin Combined with Carbamazepine in the Treatment of Refractory Epilepsy

作　　者：张红丽 郑建波 ZHANG Hongli;ZHENG Jianbo(Department of Neurology,Gucheng County People’s Hospital,Gucheng 441700,Hubei,China)

机构地区：[1]谷城县人民医院神经内科,湖北谷城441700

出　　处：《中国药物滥用防治杂志》2024年第8期1397-1399,1404,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨加巴喷丁配合卡马西平治疗难治性癫痫的效果。方法:将2022年3月—2023年1月我院诊治的102例难治性癫痫患者按数字抽签法分为对照组(51例)与试验组(51例),对照组予以卡马西平治疗,试验组予以加巴喷丁配合卡马西平治疗。比较两组总体疗效、癫痫发作频率、脑电图指标。结果:治疗后,试验组治疗总有效率为88.24%,高于对照组的70.59%(P<0.05);试验组癫痫发作频率少于对照组、发作持续时间短于对照组(P<0.05);试验组α频段、β频段脑电相对功率高于对照组,δ频段、θ频段脑电相对功率低于对照组(P<0.05)。结论:加巴喷丁配合卡马西平能增强难治性癫痫临床疗效,减少癫痫发作,并能有效改善患者脑电图指标。Objective:To explore the therapeutic effect of gabapentin combined with carbamazepine in the treatment of refractory epilepsy.Methods:From March 2022 to January 2023,102 patients with refractory epilepsy diagnosed and treated in our hospital were divided into control group(51 patients)and experimental group(51 patients)according to the digital lottery method.The control group was treated with carbamazepine,and the experimental group was treated with gabapentin combined with carbamazepine.The overall efficacy,seizure frequency and EEG indexes of the two groups were compared.Results:After treatment,the total effective rate of the experimental group was 88.24%,which was higher than 70.59%of the control group(P<0.05);the frequency of epileptic seizures in the experimental group was less than that in the control group,and the duration of seizures was shorter than that in the control group(P<0.05);the relative power ofα-band andβ-band EEG in the experimental group was higher than that in the control group,and the relative power ofδ-band andθ-band EEG was lower than that in the control group(P<0.05).Conclusion:Gabapentin combined with carbamazepine can enhance the clinical efficacy of refractory epilepsy,reduce seizures,and can effectively improve the EEG indicators of patients.

关 键 词：难治性癫痫 加巴喷丁 卡马西平 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]