蒽环类药物致乳腺癌患者心肌损伤的影响因素及右丙亚胺的预防效果  

Influencing Factors of Anthracycline-induced Myocardial Injury in Breast Cancer Patients and Preventive Effect of Dexrazoxane

作　　者：崔宁[1] 蔡锋[2] 曹武杰 王若明[1] CUI Ning;CAI Feng;CAO Wujie;WANG Ruoming(Department of Thyroid and Breast Surgery,the First People’s Hospital of Shangqiu,Shangqiu 476000,Henan,China;Department of Hepatobiliary Surgery,the First People’s Hospital of Shangqiu,Shangqiu 476000,Henan,China)

机构地区：[1]商丘市第一人民医院甲状腺乳腺外科,河南商丘476000 [2]商丘市第一人民医院肝胆外科,河南商丘476000

出　　处：《中国药物滥用防治杂志》2024年第8期1432-1436,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20200935)。

摘　　要：目的:探究蒽环类药物致乳腺癌患者心肌损伤的影响因素及右丙亚胺的预防作用。方法:回顾性分析我院2021年1月—2023年12月收治的127例接受蒽环类药物治疗的乳腺癌患者的临床资料,依据是否发生心肌损伤分为心肌损伤组(45例)、非心肌损伤组(82例),详细统计所有患者的临床资料,分析心肌损伤的危险因素。结果:心肌损伤组与非心肌损伤组年龄、BMI、高血压史、糖尿病史、HER2阳性、BNP、cTnI、CRP、TGF-β1、预防性应用右丙亚胺治疗率比较,差异有统计学意义(P<0.05)。Logistic回归发现,高龄、HER2阳性、高BNP、高cTnI、高CRP、高TGF-β1是乳腺癌患者心肌损伤的危险因素,预防性应用右丙亚胺是保护性因素(P<0.05)。结论:蒽环类药物致乳腺癌患者心肌损伤的危险因素包括年龄高、HER2阳性、高BNP水平、高cTnI水平、高CRP水平、高TGF-β1水平、未预防性应用右丙亚胺。Objective:To explore the influencing factors of anthracycline-induced myocardial injury in breast cancer patients and the preventive effect of dexrazoxane.Methods:The clinical data of 127 breast cancer patients treated with anthracycline drugs in our hospital from January 2021 to December 2023 were retrospectively analyzed.According to whether myocardial injury occurred,they were divided into myocardial injury group(45 patients)and non-myocardial injury group(82 patients).The clinical data of all patients were counted in detail,and the risk factors of myocardial injury were analyzed.Results:There were significant differences in age,BMI,history of hypertension,history of diabetes,HER2 positive,BNP,cTnI,CRP,TGF-β1 and preventive application of dexrazoxane between myocardial injury group and non-myocardial injury group(P<0.05).Logistic regression showed that advanced age,HER2 positive,high BNP,high cTnI,high CRP and high TGF-β1 were risk factors for myocardial injury in patients with breast cancer,and prophylactic use of dexrazoxane was a protective factor(P<0.05).Conclusion:The risk factors of anthracycline-induced myocardial injury in breast cancer patients include high age,HER2 positive,high BNP level,high cTnI level,high CRP level,high TGF-β1 level,and no prophylactic use of dexrazoxane.

关 键 词：乳腺癌 心肌损伤 危险因素 右丙亚胺 

分 类 号：R737.9[医药卫生—肿瘤] R979.1[医药卫生—临床医学]