曲克芦丁脑蛋白水解物注射液辅助丹参多酚酸盐治疗老年急性脑梗死的效果  

Effect of Troxerutin and Cerebroprotein Hydrolysate Injection Combined with Salvianolate in the Treatment of Elderly Patients with Acute Cerebral Infarction

作　　者：张露萌 秦丽惠 郭二霞 李秋歌 张琼琼 朱稼音 ZHANG Lumeng;QIN Lihui;GUO Erxia;LI Qiuge;ZHANG Qiongqiong;ZHU Jiayin(Preparation Room,the First Department of Internal Medicine,Pingdingshan 467000,Henan,China;Preparation Room,Outpatient Pharmacy,Pingdingshan 467000,Henan,China;Preparation Room,Pingdingshan Hospital of Traditional Chinese Medicine,Pingdingshan 467000,Henan,China)

机构地区：[1]平顶山市中医医院制剂室,河南平顶山467000 [2]平顶山市中医医院制剂室内一科,河南平顶山467000 [3]平顶山市中医医院制剂室门诊西药房,河南平顶山467000

出　　处：《中国药物滥用防治杂志》2024年第8期1527-1530,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨曲克芦丁脑蛋白水解物注射液在急性脑梗死老年患者脑中的应用价值。方法:选取2020年1月—2022年12月本院收治的老年急性脑梗死患者123例作为研究对象。采用随机单双号法分为研究组(62例)和对照组(61例)。对照组予以静脉滴注丹参多酚酸盐,研究组在对照组基础上增加曲克芦丁脑蛋白水解物注射液,比较两组脑血流量、相关神经因子、自由基清除能力和安全性。结果:研究组治疗后4周SOD、相对脑血容量、BNDF和MCA、VA、BA、ECBF高于对照组,MDA、NSE和S-100β低于对照组(P<0.05),且两组均未发生严重不良反应。结论:曲克芦丁脑蛋白水解物联合丹参多酚酸盐治疗老年急性脑梗死,可高效且安全的增加脑血流量和自由基清除能力,改善脑损伤标志物水平和应激状态。Objective:To explore the application value of troxerutin and cerebroprotein hydrolysate injection in the brain of elderly patients with acute cerebral infarction.Methods:A total of 123 elderly patients with acute cerebral infarction admitted to our hospital from January 2020 to December 2022 were selected as the study subjects.They were divided into study group(62 patients)and control group(61 patients)by random single and double number method.The control group was given intravenous infusion of salvianolate,and the study group was given troxerutin and cerebroprotein hydrolysate injection on the basis of the control group.The cerebral blood flow,related nerve factors,free radical scavenging ability and safety were compared between the two groups.Results:Four weeks after treatment,SOD,relative cerebral blood volume,BNDF,MCA,VA,BA and ECBF in the study group were higher than those in the control group,while MDA,NSE and S-100βwere lower than those in the control group(P<0.05).No serious adverse reactions occurred in the two groups.Conclusion:Troxerutin cerebroprotein hydrolysate combined with salvianolate in the treatment of acute cerebral infarction in the elderly can effectively and safely increase cerebral blood flow and free radical scavenging ability,and improve the level of brain injury markers and stress state.

关 键 词：急性脑梗死 曲克芦丁脑蛋白水解物 脑血流量 神经因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]