介导骨骼肌-肝脏轴串扰的肌源性和肝源性因子在非酒精性脂肪性肝病和肌少症作用机制的新进展  

Emerging Insights into the Pathogenic Mechanisms of Myokines and Hepatokines in Muscle-liver Crosstalk:Implications for Non-alcoholic Fatty Liver Disease and Sarcopenia

作　　者：顾子微 赵宇星[1] 赵柯湘[1] 肖谦[1] Gu Ziwei;Zhao Yuxing;Zhao Kexiang;Xiao Qian(Department of Geriatrics,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016)

机构地区：[1]重庆医科大学附属第一医院老年病科,重庆400016

出　　处：《国际老年医学杂志》2024年第5期513-517,共5页International Journal of Geriatrics

基　　金：国家自然科学基金青年科学基金项目(82101652);重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0207)。

摘　　要：非酒精性脂肪性肝病(NAFLD)和肌少症是中老年人群高发的代谢性疾病,两者发病机制存在部分重叠。肝脏和骨骼肌能够合成和释放多种肝源性因子和肌源性因子,这些因子通过激活调控代谢的信号通路来维持能量稳态,介导骨骼肌-肝脏轴进行“对话”。本文就NAFLD与肌少症发病中部分肌源性因子和肝源性因子的作用机制进行综述,以揭示骨骼肌-肝脏轴之间的调控网络。Non-alcoholic fatty liver disease(NAFLD)and sarcopenia are prevalent metabolic disorders in middle-aged and elderly populations,with overlapping pathogenic mechanisms.The liver and skeletal muscle secrete hepatokines and myokines,which play crucial roles in maintaining energy homeostasis by activating metabolic signaling pathways and mediating crosstalk in the muscle-liver axis.This review explores the specific mechanisms by which myokines and hepatokines contribute to the pathogenesis of NAFLD and sarcopenia,aiming to elucidate the regulatory network between the liver and skeletal muscle.

关 键 词：非酒精性脂肪性肝病 肌少症 骨骼肌-肝脏轴 肌源性因子 肝源性因子 

分 类 号：R575.5[医药卫生—消化系统] R685[医药卫生—内科学]