术前NLR、IL-35及MTA2与前列腺癌患者术后复发及转移的相关性  

Correlation of Preoperative NLR,IL-35 and MTA2 with Postoperative Recurrence and Metastasis in Patients with Prostate Cancer

作　　者：安宁 程佳琪 何宏艳 程晓露 赵增喜[1] An Ning;Cheng Jiaqi;He Hongyan;Cheng Xiaolu;Zhao Zengxi(Department of urology,the Second Affiliated Hospital of Hebei North University 075100;Operating Room,Second Affiliated Hospital of Hebei North University 075100)

机构地区：[1]河北北方学院附属第二医院泌尿外科,张家口075100 [2]河北北方学院附属第二医院手术室,张家口075100

出　　处：《国际老年医学杂志》2024年第5期571-575,共5页International Journal of Geriatrics

基　　金：河北省卫生健康委员会科研基金项目(20231468)。

摘　　要：目的探讨术前中性粒细胞与淋巴细胞比值(NLR)、白细胞介素-35(IL-35)及转移相关蛋白2(MTA2)对前列腺癌患者术后复发及转移的预测价值。方法选取2019年6月-2022年6月在河北北方学院附属第二医院接受手术治疗的160例老年前列腺癌患者作为研究对象,根据术后有无复发或转移分为发生组(68例)和未发生组(92例)。比较两组一般资料,采用logistic回归分析NLR、IL-35、MTA2与前列腺癌患者术后复发及转移风险的相关性,ROC曲线评估各指标对前列腺癌患者术后复发及转移风险的预测价值。结果两组TNM分级、Gleason评分,NLR、IL-35及MTA2比较,差异均有统计学意义(P<0.05)。Logistic回归分析显示,在校正多个混杂因素后,NLR、IL-35水平及MTA2评分均是前列腺癌患者术后复发及转移发生的独立危险因素(P<0.05)。ROC曲线显示,NLR、IL-35水平及MTA2评分对前列腺癌患者术后复发及转移具有一定的预测价值。结论NLR、IL-35水平及MTA2评分对前列腺癌术后发生复发及转移具有一定的预测价值,对早期前列腺癌术后复发及转移的高危患者的判断和改进患者预后具有重要的临床价值。Objective To investigate the predictive value of preoperative neutrophil to lymphocyte ratio(NLR),interleukin-35(IL-35)and metastasis-associated protein 2(MTA2)for postoperative recurrence and metastasis in patients with prostate cancer.Methods A total of 160 elderly patients who received prostate cancer surgery in the Second Affiliated Hospital of Hebei North University from June 2019 to June 2022 were selected as the study subjects and divided into the occurrence group(68 cases)and the non-occurrence group(92 cases)according to the presence or absence of postoperative recurrence or metastasis.The general data of the two groups were compared,and the correlation between NLR,IL-35 and MTA2 and the risk of postoperative recurrence and metastasis in patients with prostate cancer was analyzed by logistic regression.ROC curve was used to assess the predictive value of each index for the risk of postoperative recurrence and metastasis in patients with prostate cancer.Results There were significant differences in TNM grade,Gleason score,NLR,IL-35 and MTA2 between the two groups(P<0.05).Logistic regression analysis showed that NLR,IL-35 levels and MTA2 scores were independent risk factors for postoperative recurrence and metastasis in prostate cancer patients after adjusting for multiple confounders(P<0.05).ROC curve showed that NLR,IL-35 levels and MTA2 scores had some predictive value for postoperative recurrence and metastasis in prostate cancer patients.Conclusion NLR,IL-35 levels,and MTA2 scores will have predictive value for the recurrence and metastasis of prostate cancer after surgery.They will play an important role in the early identification of high-risk patients for recurrence and metastasis after prostate cancer surgery and in improving patient prognosis.

关 键 词：中性粒细胞与淋巴细胞比值 白细胞介素-35 转移相关蛋白2 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]