From Entry to Evasion:A Comprehensive Analysis of Host-Virus Interactions for Monkeypox  

作　　者：Vahideh Hamidi Sofiani Mohammad Rezaei Zadeh Rukerd Javad Charostad Mohammad Pardeshenas Reza Ghazi Nasir Arefinia Sara Shafieipour Faranak Salajegheh Mohsen Nakhaie 

机构地区：[1]Department of Microbiology,Golestan University of Medical Sciences,Gorgan,Iran [2]Gastroenterology and Hepatology Research Center,Institute of Basic and Clinical Physiology Sciences,Kerman University of Medical Sciences,Kerman,Iran [3]Universal Scientific Education and Research Network(USERN),Tehran,Iran [4]Department of Microbiology,Faculty of Medicine,Shahid Sadoughi University of Medical Sciences,Yazd,Iran [5]Department of Microbiology,School of Medicine,Kerman University of Medical Sciences,Kerman,Iran [6]Department of Biotechnology,Golestan University of Medical Sciences,Gorgan,Iran [7]Student Research Committee,Jiroft University of Medical Sciences,Jiroft,Iran [8]Physiology Research Center,Institute of Neuropharmacology,Kerman University of Medical Sciences,Kerman,Iran [9]Clinical Research Development Unit,School of Medicine,Afzalipour Hospital,Kerman University of Medical Sciences,Kerman,Iran

出　　处：《Infectious Microbes & Diseases》2024年第2期56-64,共9页感染微生物与疾病（英文）

摘　　要：Monkeypox(Mpox)has posed a novel challenge and emerged as a threat to global public health since the onset of its outbreak in 2022.Mpox is spreading throughout the world in both endemic and non-endemic countries,indicating that its behavior is evolving.The prevalence of Mpox and the risk of a global pandemic necessitate a better understanding of Mpox virus replications and interactions with the host.Here,we attempted to provide a detailed comprehensive review of Mpox virus behavior at the molecular level from the entry level to the establishment of a successful infection,including attachment and entry,DNA replication,protein expression and viron assembly and egress.This review also describes its strategies to evade host immune responses and inhibit apoptosis,and uncovers underlying molecular mechanisms such as subverted signaling pathways and cellular factors behind host-viral interactions.

关 键 词：MONKEYPOX IMMUNITY apoptosis virus-host interaction 

分 类 号：R511[医药卫生—内科学]