督脉穴合头穴灸法对血管性痴呆患者认知功能、自理能力及氧化应激水平的影响  

Effect of moxibustion at Du meridian and scalp points on cognitive function,self-care ability and oxidative stress in patients with vascular dementia

作　　者：张盼 张晓红[2] 杜双霞[3] 韩陨 苑艳尊 李西园[5] 刘倩[6] ZHANG Pan;ZHANG Xiaohong;DU Shuangxia;HAN Yun;YUAN Yanzun;LI Xiyuan;LIU Qian(Department of Geriatrics,Baoding No.2 Central Hospital,Baoding,Hebei 072750;Department of Medical Care,Baoding No.2 Central Hospital,Baoding,Hebei 072750;Department of Neurology,Baoding No.2 Central Hospital,Baoding,Hebei 072750;Baoding No.2 Central Hospital,Baoding,Hebei 072750;Department of Critical Care Medicine,Baoding No.2 Central Hospital,Baoding,Hebei 072750;Department of Traditional Chinese Medicine,Baoding No.2 Central Hospital,Baoding,Hebei 072750)

机构地区：[1]河北省保定市第二中心医院老年病科,河北保定072750 [2]河北省保定市第二中心医院医务科,河北保定072750 [3]河北省保定市第二中心医院神经内科,河北保定072750 [4]河北省保定市第二中心医院,河北保定072750 [5]河北省保定市第二中心医院重症医学科,河北保定072750 [6]河北省保定市第二中心医院中医科,河北保定072750

出　　处：《河北中医》2024年第9期1512-1515,1519,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：保定市科技计划项目(编号:2041ZF026)。

摘　　要：目的研究督脉穴合头穴灸法对血管性痴呆患者认知功能、自理能力及氧化应激水平的影响。方法将保定市第二中心医院神经内科2021年1月至2022年1月收治的82例血管性痴呆患者按随机数字表法分为对照组及治疗组,各41例,2组均行常规药物治疗,对照组加常规健康宣教、病情监测、服药指导及康复锻炼,治疗组在对照组基础上加用督脉穴合头穴灸法,共治疗4周。比较2组治疗前后中医证候评分、简易精神状态量表(MMSE)评分、日常生活自理能力量表(ADL)评分及丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)及C反应蛋白(CRP)水平。结果2组治疗后中医证候评分均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05)。2组治疗后MMSE、ADL评分均较本组治疗前升高(P<0.05),且治疗组高于对照组(P<0.05)。2组治疗后MDA、IL-6、TNF-α及CRP水平均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05);2组治疗后SOD、GSH-Px水平均较本组治疗前升高(P<0.05),且治疗组高于对照组(P<0.05)。结论督脉穴合头穴灸法能改善血管性痴呆患者认知功能、自理能力及氧化应激状态。Objective To study the effect of moxibustion at Du meridian and scalp points on cognitive function,self-care ability and oxidative stress in patients with vascular dementia(VD).Methods Totally 82 VD patients admitted to Neurology Department of Baoding No.2 Central Hospital from January 2021 to January 2022 were randomly assigned into control group(n=41)and treatment group(n=41).All patients were managed by routine medicine,routine health education,disease monitoring,medication instruction,rehabilitative exercise,and those in treatment group were additionally treated with moxibustion at Du meridian and scalp points.Treated for 4 weeks,the aim was to compare traditional Chinese medicine(TCM)syndrome scores,Mini-Mental State Examination(MMSE)score,activities of daily living(ADL)scale,malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP).Results After treatment,TCM symptom scores in both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).MMSE and ADL scores in both groups were significantly increased(P<0.05),which were significantly increased in the treatment group relevant to the control group(P<0.05).MDA,IL-6,TNF-α,CRP in both groups were significantly decreased(P<0.05),which were significantly decreased in the treatment group than in the control group(P<0.05).SOD and GSH-Px levels in both groups were significantly increased(P<0.05),the increase in the treatment group was more common than the control group(P<0.05).Conclusion For VD patients,the moxibustion at Du meridian and scalp points can improve cognitive function,self-care ability and oxidative stress status.

关 键 词：痴呆 血管性 督灸疗法 头穴 认知 氧化应激 

分 类 号：R743.905[医药卫生—神经病学与精神病学] R246.1[医药卫生—临床医学]